2010

  • Salin O., Alakurtti S., Pohjala L., Siiskonen A., Maass V., Maass M, Yli-Kauhaluoma J., Vuorela P. (2010): Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae. Biochemical Pharmacology 80:1141-1151.

  • Keurulainen L., Salin O., Siiskonen A., Kern J.M., Maas M., Yli-Kauhaluoma J., Vuorela P. (2010): Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. Journal of Medicinal Chemistry 53:7664-7674.

  • Yli-Kauhaluoma, J., Koskimies, S., Alakurtti, S., Bergström, P., Mäkelä, T., Vuorela, P., Tammela, P., Minkkinen, J., Pohjala, L.: Betuliiniperäiset yhdisteet antimikrobisina aineina - Betulin härstammande föreningar som antimikrobiska föreningar. Pat. No. Appl. 20065388. Betulin-derived Compounds as Antimicrobial Agents. Finn. Pat. FI 121468 B, 30.11.2010.

  • Varhimo E.; Varmanen P.; Fallarero A.; Skogman M.; Pyörälä S.; Iivanainen A.; Sukura A.; Vuorela P. and Savijoki K. Alpha- and β-casein components of host milk induce biofilm formation in the mastitis bacterium Streptococcus uberis. (2010). Veterinary Microbiology Nov 12. [Epub ahead of print]

  • Schütz, P., Karlberg, T., van den Berg, S., Collins, R., Lehtiö, L., Högbom, M., Holmberg-Schiavone, L., Tempel, W., Park, H-W., Hammarström, M., Moche, M., Thorsell, A.-G. & Schüler, H. (2010) Comparative Structural Analysis of Human DEAD-Box RNA Helicases. PLoS One 5:e12791

  • Nyman, T., Trésaugues, L., Welin, M., Lehtiö, L., Flodin, S., Persson, C., Johansson, I., Hammarström, M. & Nordlund, P. (2010) The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface. PLoS One 5:e12907

  • Welin, M., Grossmann, J.G., Flodin, S., Nyman, T., Stenmark, P., Trésaugues, L., Kotenyova, T., Johansson, I., Nordlund, P. & Lehtiö, L. (2010) Structural studies of tri-functional human GART. Nucleic Acids Res. 38:7308-7319.

  • Siponen, M.I., Wisniewska, M., Lehtiö, L., Johansson, I., Svensson, L., Raszewski, G., Nilsson, L., Sigvardsson, M. & Berglund, H. (2010) Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif. J. Biol. Chem. 285:25875-25879.

  • Sandler N ., Reiche K., Heinämäki J., Yliruusi J. Effect of Moisture on Powder Flow Properties of Theophylline. Pharmaceutics. 2010; 2(3):275-290.

  • Soppela I, Airaksinen S, Murtomaa M, Tenho M, Räikkönen H, Hatara J, Yliruusi J, Sandler N. Investigation of the powder flow behaviour of binary mixtures of microcrystalline celluloses and paracetamol, J. Excipients and Food Chem. 1 (1) 2010, 55-67

  • Tuominen, H., Salminen, A., Oksanen, E., Jämsen, J., Heikkilä, O., Lehtiö, L., Magretova, N.N., Goldman, A., Baykov, A.A. & Lahti R. (2010) Crystal structures of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP, and activator, diadenosine tetraphosphate. J. Mol. Biol. 398:400-13.

  • Wisniewska, M., Karlberg, T., Lehtiö, L., Johansson, I., Kotenyova, T., Moche, M. & Schüler, H. (2010) Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78. PLoS One 5:e8625

  • Loseva, O., Jemth, A.-S., Bryant, H.E., Schüler, H., Lehtiö, L., Karlberg, T. & Helleday, T. (2010) Poly(ADP-ribose) polymerase-3 (PARP-3) is a mono-ADP ribosylase that activates PARP-1 in absence of DNA. J. Biol. Chem. 285:8054-60.

  • Garcia Mir V; Heinämaki JT; Antikainen O; Sandler N; Revoredo OB; Colarte AI; Nieto OM; Yliruusi J. Application of crustacean chitin as a co-diluent in direct compression of tablets, In Press AAPS PharmSciTech 2010

  • Kivikero N, Murtomaa M, Anitikainen O, Juppo A, Sandler N, Excipient screening for microscale granulation using electrostatic atomization, In press Pharm.Dev Tech. 2010

  • Sandler N and Wilson D. Prediction of granule packing and flow behavior based on particle size and shape analysis, J.Pharm.Sci, 99:2 (2010) 958-968

  • Riihimäki-Lampén L., Vainio m., Vahermo M., Pohjala L., Heikura J., Valkonen K., Virtanen V., Yli-Kauhaluoma J., Vuorela P. (2010): The binding of synthetic retinoids to lipocalin β-lactoglobulins. Journal of Medicinal Chemistry53:514-518.

  • Alptüzün V., Prinz M., Hörr V., Scheiber J., Radacki K., Fallarero A., Vuorela P., Engels B., Braunschweig H., Erciyas E., Holzgrabe U. (2010): Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine and butyrylcholine esterases Bioorganic & Medicinal Chemistry 18:2049-2059.

  • Järvinen P.; Fallarero A.; Gupta S.; Mohan G.C.; Hatakka A. and Vuorela P. Miniaturization and validation of the Ellman's reaction based acetylcholinesterase inhibitory assay into 384-well plate format and screening of a chemical library. (2010). Combinatorial Chemistry and High Throughput Screening. 13(3):278-84.

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https://www.abo.fi/amnen/farmaci/

Pharmaceutical Sciences

Åbo Akademi University

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FI 20520 Turku

Finland

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