Research group: Precision Nanomedicine and Diagnostic Group

Nanobiotechnology is a novel discipline that indicate the merger of biological and nanotechnology. It is a multidisciplinary subject, which interplay between physics, materials science, synthetic organic chemistry, engineering and biology.

To efficiently diagnostic and treat diseases, the understanding of detail mechanism of disease occur would be critical. The qualitative and quantitative analysis at the molecular scope in real time is highly demanded but very challenging to achieve. Nanobiotechnology is to solve the fascinating problems offered by biology through designing and synthesizing of specific nanomaterials and utilize specific techniques.

DNA nanotechnology is one important example of nanobiotechnology. As the central genetic molecule in biological systems, DNA possesses many exceptional properties, including its biological function, biocompatibility, molecular recognition ability, and nanoscale controllability. These unique attributes enabled the creation of functional DNA nanostructures, which act as natural bridge between nanotechnology and biotechnology, leading to far-ranging real-world applications.

Microfluidic technology is revolutionary for high throughput diagnostics and other biological applications. We are collaborating with Prof. David. A Weitz in Harvard University (http://weitzlab.seas.harvard.edu) and we will develop and utilize microfluidic techniques for Single Cell RNA-Sequencing, Single-cell analysis and screening; on-chip screening, diagnostic; and microfluidic templated nano/micro-particles fabrication and encapsulation.

Contact: hongbo.zhang@abo.fi

Publications

2019 (13)

[82] Yimin Wang, Di Wu, Guohua Wu, Jianguo Wu, Siming Lu, James Lo, Yong He, Chao Zhao, Xin Zhao, Hongbo Zhang, ShuQi Wang. "Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy". Theranostics 2019; doi:10.7150/thno.38736; in press 

[81] Yangyang Li, Yuchen Qi, Hongbo Zhang, Zhiming Xia, Tingting Xie, Wanlin Li, Danni Zhong, Huanle Zhu, Min Zhou, "Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostics", Biomaterials, 2019, 119538

[80] Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang*, Hélder A. Santos*, Hongxing Shen*, “Gene-Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus”, Adv. Sci. 2019. (in press)

[79Jincheng Tang, Yong Gu, Hongbo Zhang, Liang Wu, Yun Xu, Jiannan Mao, Tianwen Xin, Ingjun Ye, Lianfu Deng, Wenguo Cui, Hélder A. Santos, Liang Chen“Outer-Inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis”, Nanoscale 2019. (accepted) 

[78] Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu, Lu Gan*, Hélder A. Santos*, Xiangliang Yang*, “Tumor Exosome-Based Nanoparticles are Efficient Drug Carriers for Chemotherapy”, Nature Commun. 2019. (accepted)​

[77] Diosangeles Soto Veliz*, Hongbo Zhang, Martti Toivakka. "Stacking up: a new approach for cell culture studies".  Biomaterials Science, 2019. 

[76] Ranjith Kumar Kankala, Hongbo Zhang, Chen-Guang Liu, Kiran Reddy Kanubaddi, Chia-Hung Lee, Shi-Bin Wang, Wenguo Cui*, Hélder A. Santos*, KaiLi Lin*, Ai-Zheng Chen*, “Metal Species-Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs”, Adv. Funct. Mater. 2019. (Review) (accepted)

[75] Yue Qiao, Yuan Ping, Hongbo Zhang, Fengyong Liu, Bo Zhou, Yinhui Yu, Tingting Xie, Wanli Li, Danni Zhong, Yuezhou Zhang, Ke Yao, Hélder A. Santos*, Min Zhou*, “Laser Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Wound Healing for Infected Chronic Nonhealing Wounds”, ACS Appl. Mater. Interfaces 2019, 11(4), 3809–3822.

[74] Hongbo Zhang, Wenguo Cui, Xiangmeng Qu, Huayin Wu, Liangliang Qu, Xu Zhang, Ermei Mäkilä, Jarno Salonen, Yue-Qi Zhu*, Zhou Yang, Dong Chen, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Photothermal Responsive Nanosized Hybrid Polymersome as Versatile Therapeutics Co-Delivery Nanovehicle for Effective Tumor Suppression”, Proc. Natl. Acad. Sci. U.S.A. 2019. (accepted)

[73] Xiaodong Ma,  Ezgi Ozliseli,  Yuezhou Zhang,  Guoqing Pan,  Dongqing WangHongbo Zhang*. ​"Fabrication of Redox- Responsive Doxorubicin and Paclitaxel Prodrug Nanoparticles with Microfluidics for Selective Cancer Therapy". Biomaterials Science, 2019. 

[72] Yufei Yan, Hao Chen, Hongbo Zhang, Changjun Guo, Kai Yang, Kaizhe Chen, Ruoyu Cheng, Niandong Qian, Niklas Sandler, Yu Shrike Zhang, Haokai Shen, Jin Qi, Wenguo Cui, Lianfu Deng. Vascularized 3D printed scaffolds for promoting bone regeneration. Biomaterials, 2018 https://doi.org/10.1016/j.biomaterials.2018.10.033

[71] Zehua Liu, Yunzhan Li, Wei Li, Wenhua Lian, Marianna Kemell, Sami Hietala, Patrícia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang*, Xianming Deng*, Hélder A. Santos.* Close-loop Dynamic Nanohybrids on Collagen-Ark with In-situ Gelling Transformation Capability for Bio-mimetically Stage Specific Diabetic Wound Healing. Material Horizon. 2019 Accepted.  
[70] Yufei Yan, Tao Sun, Hongbo Zhang, Xiuling Ji, Yulong Sun, Xin Zhao, Lianfu Deng, Jin Qi*, Wenguo Cui*, Hélder A. Santos*, Hongyu Zhang*, “Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis”, Adv. Funct. Mater. 2019. (accepted)

2018 (20)

[69] Yuezhou Zhang, Dongfei Liu, Hongbo Zhang, Hélder A. Santos,* "Chapter 7: Microfluidic Mixing and Devices for Preparing Nanoparticulate Drug Delivery Systems". In: Microfluidics for pharmaceutical applications: from nano/micro systems fabrication to controlled drug delivery, Santos H. A., Liu D., and Zhang H. (Eds.), Elsevier B.V. 2018, 155–177.

[68] Xiaobin Guo, Yu Liu, Jiaxiang Bai, Binqing Yu, Menglei XuHouyi Sun, Jining Shen, Jiayi Lin, Hongbo ZhangDongqing WangDechun Geng, Guoqing Pan, "Efficient Inhibition of Wear‐Debris‐Induced Osteolysis by Surface Biomimetic Engineering of Titanium Implant with a Mussel‐Derived Integrin‐Targeting Peptide", Advanced Biosystems, 2018 Accepted. 

[67] Shengcai Qi, Pengfei Zhang, Ming Ma*, Minghua Yao, Jinjin Wu, Ermei Mäkilä, Jarno Salonen, Heikki Ruskoaho, Yuanzhi Xu, Hélder A. Santos*, Hongbo Zhang*, “Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells”, Small 2019. (accepted)

[66] Xiyuan Mao, Ruoyu Cheng, Hongbo Zhang, Jinhong Bae, Liying Cheng, Lu Zhang, Lianfu Deng, Wenguo Cui*, Yuguang Zhang*, Hélder A. Santos*, Xiaoming Sun*, “Self-Healing and Injectable Hydrogel for Matching Skin Flap Regeneration”, Adv. Sci. 2018. (accepted)

[65] Yueqi Zhu, Hongbo Zhang, Yiran Zhang, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng*, Minghua Li*, Hélder A. Santos*, Wenguo Cui*, “Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases”, Adv. Mater. 2018. (accepted)

[64] Minghua Yao, Ming Ma*, Hongbo Zhang, Gang Wan, Yuezhou Zhang, Hangrong Chen*, Rong Wu*, “Theranostic Role of Cobalt Protoporphyrin Nano-Formulation for Photoacoustic Imaging Guided Stem Cell Implantation”. Adv. Funct. Mater. 2018. (accepted)

[63] Wei Li, Yunzhan Li, Zehua Liu, Nattha Kerdsakundee, Ming Zhang, Feng Zhang, Xueyan Liu, Tomás Bauleth-Ramos, Wenhua Lian, Ermei Mäkilä, Marianna Kemell, Yaping Ding, Bruno Sarmento, Ruedeekorn Wiwattanapatapee, Jarno Salonen, Hongbo Zhang, Jouni T. Hirvonen, Dongfei Liu*, Xianming Deng*, Hélder A. Santos*, “Hierarchical Structured and Programmed Vehicles Deliver Drugs Locally to Inflamed Sites of Intestine”, Biomaterials 2018, 185, 322-332.

[62] Xingzhi Liu, Hongbo Zhang, Ruoyu Cheng, Yanzheng Gu, Yin Yin, Zhiyong Sun, Guoqing Pan, Zhongbin Deng, Huilin Yang, Lianfu Deng, Wenguo Cui*,  Hélder A Santos*, Qin Shi*, “Immunological Electrospun Scaffold for Tumor Imprison Killing and Healthy Tissue Regeneration”, Mater. Horiz. 2018. (in press)

[61] Xiaoming Sun, Hongbo Zhang, Jinlin He, Ruoyu Cheng, Youwen Cao, Kunming Che, Liying Cheng, Lu Zhang, Guoqing Pan, Peihong Ni, Lianfu Deng, Yuguang Zhang*, Hélder A. Santos*, Wenguo Cui*, “Adjustable hardness of hydrogel for promoting vascularization and maintaining stemness of stem cells in skin flap regeneration”, Appl. Mater. Today 2018, 13, 54-63.

[60] Guanggai Xia, Hongbo Zhang, Ruoyu Cheng, Hongcheng Wang, Ziliang Song, Lianfu Deng, Xinyu Huang*, Hélder A. Santos*, Wenguo Cui*, “Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence”, Adv. Healthcare Mater. 2018. (accepted)

[59] Dongfei Liu*, Katriina Lipponen, Peng Quan, Xiaocao Wan, Hongbo Zhang, Ermei Mäkilä, Jarno Salonen, Risto Kostiainen, Jouni Hirvonen, Tapio Kotiaho, and Hélder A. Santos*. Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions. ACS Biomaterials Science§Engineering, 2018 

[58] Book editing: Microfluidics for Pharmaceutical Applications, 560 pages, ISBN 9780128126592 . 

[57]Jianfeng Ji, Fei Ma, Hongbo Zhang, Fengyong Liu, Jian He, Wanlin Li, Tingting Xie, Danni Zhong, Tingting Zhang, Mei Tian*, Hong Zhang*, Hélder A. Santos*, Min Zhou*, “Light-Activatable Assembled Nanoparticles to Improve Tumor-Penetration and Eradicate Metastasis in Triple Negative Breast Cancer”, Adv. Funct. Mater. 2018. (accepted)

[56]Feng Zhang, Li Kong, Dongfei Liu, Wei Li, Ermei Mäkilä, Alexandra Correia, Rici Lindgren, Jarno Salonen, Jouni J. Hirvonen, Hongbo Zhang, Alexander Kros, Hélder A. Santos*, “Sequential Antifouling Surface for Efficient Modulation of the Nanoparticle-Cell Interactions in Protein-Rich Environment”, Adv. Ther. 2018. (accepted)

[55]Ruibo Zhong, Qian Tang, Shaopeng Wang, Hongbo Zhang, Feng Zhang, Mingshu Xiao, Tiantian Man, Xiangmeng Qu, Li Li, Weijia Zhang, Hao Pei.* “Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors”. Advanced Materials 2018. DOI: 10.1002/adma.201706887 (In Press).

[54]Vimalkumar Balasubramanian, Andrea Poillucci, Alexandra Correia, Hongbo Zhang, Christian Celia, Hélder A. Santos*, “Cell Membranes based Nanoreactor to Mimic the Bio-Compartmentalization Strategy of a Cell”, ACS Biomater. Sci. Eng. 2018. (in press)

[53]Hongbo Zhang, Yueqi Zhu, Liangliang Qu, Huayin Wu, Haixin Kong, Zhou Yang, Dong Chen, Ermei Makila, Jarno J. Salonen, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates”, Nano Lett. 2018. (in press)

[52]Y. Zhang*, J. Tu, D. Wang, H. Zhu, S. Kumar Maity, X. Qu, B. Bogaert, H. Pei, H. Zhang*. Programmable and Multifunctional DNA-Based Materials for Biomedical Applications. Advanced Materials 2018

[51]Zehua Liu, Yunzhan Li, Wei Li, Chen Xiao, Dongfei Liu, Chao Dong, Ming Zhang, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni T. Hirvonen, Hongbo Zhang*, Dawang Zhou*, Xianming Deng*, Hélder A. Santos*, “Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics”, Adv. Mater. 2018. 

[50]Zoran Cenev, Hongbo Zhang*, Veikko Sariola, Antti Rahikkala, Dongfei Liu, Hélder A. Santos*, Quan Zhou*, “Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle”, Adv. Mater. Technol. 2018

2017 (18)

[49]Xiangmeng Qu, Min Li, Hongbo Zhang, Chenglie Lin, Fei Wang, Mingshu Xiao, Yi Zhou, Jiye Shi, Ali Aldalbahi, Hao Pei, Hong Chen, Li Li. Real-Time Continuous Identification of Greenhouse Plant Pathogens Based on Recyclable Microfluidic Bioassay System. ACS Applied Materials & Interfaces 2017, 9 (37), pp 31568–31575

[48]Hongbo Zhang, Xiangmeng Qu, Hong Chen, Ruihua Ding, Dong Chen, Weixia Zhang, Xu Zhang, Hao Pei, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Fabrication of Calcium Phosphate-based Nanocomposites Containing DNA Origami, Gold nanorods and Drugs for Synergistic Anticancer Applications”, Adv. Healthcare Mater. 2017. (accepted)

[47]Tomás Bauleth-Ramos, Mohammad-Ali Shahbazi*, Dongfei Liu, Flavia Fontana, Alexandra Correia, Patrícia Figueiredo, Hongbo Zhang, João Pedro Martins, Jouni T. Hirvonen, Pedro Granja, Bruno Sarmento*, Hélder A. Santos*, “Nutlin-3a and Cytokine co-loaded Spermine-modified Acetalated Dextran Nanoparticles for Cancer Chemo-immunotherapy”, Adv. Funct. Mater. 2017. (accepted)

[46]Dongfei Liu*, Hongbo Zhang, Flavia Fontana, Jouni T. Hirvonen, Hélder A. Santos*, “Current Developments and Applications of Microfluidic Technology Toward Clinical Translation of Nanomedicines”, Adv. Drug Deliv. Rev. 2017. (Invited Review) (in press)

[45]C. Sahlgren, A. Meinander, H. Zhang, F. Cheng, M. Preis, C. Xu, T. Salminen, D. Toivola, D. Abankwa, D. Şen Karaman, O.M.H. Salo-Ahen, R. Österbacka, J.E. Eriksson, S. Willför, I. Petre, J. Peltonen, R. Leino, M. Johnson, J. Rosenholm, N. Sandler, Tailored approaches in drug development and diagnostics – from molecular design to biological model systems (Review). Advanced Healthcare Materials, in press.

[44]Henni Auvinen, Hongbo Zhang, Nonappa, Alisa Kopilow, Elina H. Niemelä, Sami Nummelin, Alexandra Correia, Hélder A. Santos, Veikko Linko*, Mauri A. Kostiainen*, “Protein Coating of DNA Nanostructures for Enhanced Delivery, Stability and Immunocompatibility”, Adv. Healthcare Mater. 2017. (in press)

[43]Xiangmeng QuFan YangHong ChenJiang LiHongbo ZhangGuo-Jun ZhangLi LiLihua WangShiping SongYang Tian, and Hao Pei*. "Bubble-Mediated Ultrasensitive Multiplex Detection of Metal Ions in Three-Dimensional DNA Nanostructure-Encoded Microchannels". ACS Appl. Mater. Interfaces 2017. 

[42]Agne Janoniene#, Zehua Liu#, Lina Baranauskiene, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni Hirvonen, Honbgo Zhang*, Vilma Petrikaite*, Hélder A. Santos*, “A Versatile Carbonic Anhydrase IX Targeting Ligand Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging”, ACS Appl. Mater. Interfaces 2017. 

[41] Elisa Ollikainen, Dongfei Liu, Arttu Kallio, Ermei Mäkilä, Hongbo Zhang, Jarno Salonen, Hélder A. Santos, Tiina Sikanen*, “The Impact of Porous Silicon Nanoparticles on Human Cytochrome P450 Metabolism in Human Liver Microsomes In Vitro”, Eur. J. Pharm. Sci. 2017. (in press)

[40] H. Zhang*, D. Liu, L. Wang, Z. Liu, R. Wu, A. Janoniene, M. Ma, G. Pan, L. Baranauskiene, L. Zhang, W. Cui, V. Petrikaite, D. Matulis, H. Zhao, J. Pan*, H.A. Santos*, Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy, Adv Healthc Mater, (2017).

[39] F. Zhang, A. Correia, E. Makila, W. Li, J. Salonen, J.J. Hirvonen, H. Zhang*, H.A. Santos*, Receptor-Mediated Surface Charge Inversion Platform Based on Porous Silicon Nanoparticles for Efficient Cancer Cell Recognition and Combination Therapy, ACS Appl. Mater. Interfaces, (2017).

[38] X. Sun#, Q. Lang#, H. Zhang#, L. Cheng, Y. Zhang, G. Pan, X. Zhao, H. Yang, Y. Zhang, H.A. Santos*, Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration, Adv. Funct. Mater., 27 (2017).

[37] X. Qu, H. Zhang, H. Chen, A. Aldalbahi, L. Li, Y. Tian, D.A. Weitz, H. Pei*, Convection-Driven Pull-Down Assays in Nanoliter Droplets Using Scaffolded Aptamers, Anal. Chem., (2017).

[36] D. Liu, H. Zhang, S. Cito, J. Fan, E.M. Mäkilä, J.J. Salonen, J. Hirvonen, T.M. Sikanen, D.A. Weitz, H.A. Santos*, Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation, Nano Lett., (2017).

[35] W. Li, D. Liu, H. Zhang, A. Correia, E. Mäkilä, J. Salonen, J. Hirvonen, H.A. Santos*, Microfluidic assembly of a nano-in-micro dual drug delivery platform composed of halloysite nanotubes and a pH-responsive polymer for colon cancer therapy, Acta Biomater., 48 (2017) 238-246.

[34] B. Herranz-Blanco*, E. Ginestar, H. Zhang, J. Hirvonen, H.A. Santos*, Microfluidics platform for glass capillaries and its application in droplet and nanoparticle fabrication, Int. J. Pharm., 516 (2017) 100-105.

[33] L. Chen, J. Chao, X. Qu, H. Zhang, D. Zhu, S. Su, A. Aldalbahi, L. Wang, H. Pei*, Probing Cellular Molecules with PolyA-Based Engineered Aptamer Nanobeacon, ACS Appl. Mater. Interfaces, 9 (2017) 8014-8020.

[32] V. Balasubramanian*, A. Correia, H. Zhang, F. Fontana, E. Mäkilä, J. Salonen, J. Hirvonen, H.A. Santos*, Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle‐Like Functions, Adv. Mater., (2017).

 

2016 (10)

[31] R. Wu#, H. Zhang#, J. Pan, H. Zhu, Y. Ma, W. Cui, H.A. Santos*, G. Pan*, Spatio‐Design of Multidimensional Prickly Zn‐Doped CuO Nanoparticle for Efficient Bacterial Killing, Advanced Materials Interfaces, 3 (2016).

[30] A. Ora, E. Järvihaavisto, H. Zhang, H. Auvinen, H.A. Santos, M.A. Kostiainen, V. Linko, Cellular delivery of enzyme-loaded DNA origami, Chem. Commun., 52 (2016) 14161-14164.

[29] Z. Liu, V. Balasubramanian, C. Bhat, M. Vahermo, E. Mäkilä, M. Kemell, F. Fontana, A. Janoniene, V. Petrikaite, J. Salonen, J. Hirvonen, H. Zhang*, HA. Santos*. Quercetin‐Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin‐Resistant Cancer Cells, Adv. Healthc. Mater., (2016).

[28] D. Liu, T. Jiang, W. Cai, J. Chen, H. Zhang, S. Hietala, H.A. Santos, G. Yin, J. Fan, An In Situ Gelling Drug Delivery System for Improved Recovery after Spinal Cord Injury, Adv. Healthc. Mater., 5 (2016) 1513-1521.

[27] F. Kong#, H. Zhang#, X. Zhang, D. Liu, D. Chen, W. Zhang, L. Zhang, H.A. Santos, M. Hai*, Biodegradable Photothermal and pH Responsive Calcium Carbonate@ Phospholipid@ Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications, Adv. Funct. Mater., 26 (2016) 6158-6169.

[26] F. Kong#, H. Zhang#, X. Qu, X. Zhang, D. Chen, R. Ding, E. Mäkilä, J. Salonen, H.A. Santos, M. Hai*, Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle‐functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy, Adv. Mater., 28 (2016) 10195-10203.

[25] H. Guo, D. Liu, B. Gao, X. Zhang, M. You, H. Ren, H. Zhang, H.A. Santos*, F. Xu*, Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine Based on 3D Tumor Models, Molecules, 21 (2016) 954.

[24] F. Fontana, M.A. Shahbazi, D. Liu, H. Zhang, E. Mäkilä, J. Salonen, J.T. Hirvonen, H.A. Santos*, Multistaged Nanovaccines Based on Porous Silicon@ Acetalated Dextran@ Cancer Cell Membrane for Cancer Immunotherapy, Adv. Mater., (2016).

[23] M.P. Ferreira, S. Ranjan, A.M. Correia, E.M. Mäkilä, S.M. Kinnunen, H. Zhang, M.-A. Shahbazi, P.V. Almeida, J.J. Salonen, H.J. Ruskoaho*, In vitro and in vivo assessment of heart-homing porous silicon nanoparticles, Biomaterials, 94 (2016) 93-104.

[22] H. Chen, P. Jia, H. Kang, H. Zhang, Y. Liu, P. Yang, Y. Yan, G. Zuo, L. Guo, M. Jiang, Upregulating Hif‐1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound, Adv. Healthc. Mater., (2016).

 

2015 (5)

[21] R. Vasiliauskas, D. Liu, S. Cito, H. Zhang, M.-A. Shahbazi, T. Sikanen, L. Mazutis, H.A. Santos*, Simple microfluidic approach to fabricate monodisperse hollow microparticles for multidrug delivery, ACS Appl. Mater. Inter., 7 (2015) 14822-14832.

[20] S. Näkki, J. Rytkönen, T. Nissinen, C. Florea, J. Riikonen, P. Ek, H. Zhang, H.A. Santos, A. Närvänen, W. Xu*, Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration, Acta Biomater., 13 (2015) 207-215.

[19] D.F. Liu*, H.B. Zhang, E. Mäkilä, J. Fan, B. Herranz-Blanco, C.F. Wang, R. Rosa, A.J. Ribeiro, J. Salonen, J. Hirvonen, H.A. Santos*, Microfluidic assisted one-step fabrication of porous silicon@acetalated dextran nanocomposites for precisely controlled combination chemotherapy, Biomaterials, 39 (2015) 249-259.

[18] F. Kong#, X. Zhang#, H. Zhang#, X. Qu, D. Chen, M. Servos, E. Mäkilä, J. Salonen, H.A. Santos, M. Hai, Inhibition of Multidrug Resistance of Cancer Cells by Co‐Delivery of DNA Nanostructures and Drugs Using Porous Silicon Nanoparticles@ Giant Liposomes, Adv. Funct. Mater., 25 (2015) 3330-3340.

[17] B. Herranz‐Blanco, D. Liu, E. Mäkilä, M.A. Shahbazi, E. Ginestar, H. Zhang, V. Aseyev, V. Balasubramanian, J. Salonen, J. Hirvonen, On‐Chip Self‐Assembly of a Smart Hybrid Nanocomposite for Antitumoral Applications, Adv. Funct. Mater., 25 (2015) 1488-1497.

 

2014 (4)

[16] H. Zhang, M.-A. Shahbazi, P.V. Almeida, H.A. Santos, Mucus as a barrier for biopharmaceuticals and drug delivery systems,  Mucosal Delivery of Biopharmaceuticals, Springer US2014, pp. 59-97.

[15] H. Zhang, D. Liu, M.A. Shahbazi, E. Mäkilä, B. Herranz‐Blanco, J. Salonen, J. Hirvonen, H.A. Santos, Fabrication of a Multifunctional Nano‐in‐micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix, Adv. Mater., 26 (2014) 4497-4503.

[14] N. Shrestha, M.-A. Shahbazi, F. Araújo, H. Zhang, E.M. Mäkilä, J. Kauppila, B. Sarmento, J.J. Salonen, J.T. Hirvonen, H.A. Santos, Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers, Biomaterials, 35 (2014) 7172-7179.

[13] D. Liu, H. Zhang, B. Herranz‐Blanco, E. Mäkilä, V.P. Lehto, J. Salonen, J. Hirvonen, H.A. Santos, Microfluidic Assembly of Monodisperse Multistage pH‐Responsive Polymer/Porous Silicon Composites for Precisely Controlled Multi‐Drug Delivery, Small, 10 (2014) 2029-2038.

 

 

2013 (4)

[12] H. Zhang, M.-A. Shahbazi, E.M. Mäkilä, T.H. da Silva, R.L. Reis, J.J. Salonen, J.T. Hirvonen, H.A. Santos, Diatom silica microparticles for sustained release and permeation enhancement following oral delivery of prednisone and mesalamine, Biomaterials, 34 (2013) 9210-9219.

[11] T. Suominen, P. Uutela, R.A. Ketola, J. Bergquist, L. Hillered, M. Finel, H. Zhang, A. Laakso, R. Kostiainen, Determination of serotonin and dopamine metabolites in human brain microdialysis and cerebrospinal fluid samples by UPLC-MS/MS: discovery of intact glucuronide and sulfate conjugates, Plos One, 8 (2013) e68007.

[10] M.-A. Shahbazi, M. Hamidi, E.M. Mäkilä, H. Zhang, P.V. Almeida, M. Kaasalainen, J.J. Salonen, J.T. Hirvonen, H.A. Santos, The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility, Biomaterials, 34 (2013) 7776-7789.

[9] D. Liu, E. Mäkilä, H. Zhang, B. Herranz, M. Kaasalainen, P. Kinnari, J. Salonen, J. Hirvonen, H.A. Santos, Nanostructured Porous Silicon‐Solid Lipid Nanocomposite: Towards Enhanced Cytocompatibility and Stability, Reduced Cellular Association, and Prolonged Drug Release, Adv. Funct. Mater., 23 (2013) 1893-1902.

 

2012 (4)

[8] L. Zhu, G. Ge, H. Zhang, H. Liu, G. He, S. Liang, Y. Zhang, Z. Fang, P. Dong, M. Finel, Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms, Drug Metab. Disposition, 40 (2012) 529-538.

[7] H. Zhang, A. Soikkeli, A. Tolonen, T. Rousu, J. Hirvonen, M. Finel, Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases, Toxicol. In Vitro, 26 (2012) 1286-1293.

[6] H. Zhang, A.-S. Patana, P.I. Mackenzie, S. Ikushiro, A. Goldman, M. Finel, Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics, Drug Metab. Disposition, 40 (2012) 1935-1944.

[5] H. Zhang, UGTs and glucuronidation analyses in Caco-2 cells, human microsomes and recombinant enzymes, (2012).

 

Before 2012 (4)

[4] H. Zhang, A. Tolonen, T. Rousu, J. Hirvonen, M. Finel, Effects of cell differentiation and assay conditions on the UDP-glucuronosyltransferases activity in Caco-2 cells, Drug Metab. Disposition, (2010) dmd. 110.036582.

[3] J. Telenius, A.E. Wallin, M. Straka, H. Zhang, E.J. Mancini, R. Tuma, RNA packaging motor: From structure to quantum mechanical modelling and sequential-stochastic mechanism, Computational and Mathematical Methods in Medicine, 9 (2008) 351-369.

[2] S. Siissalo, H. Zhang, E. Stilgenbauer, A.M. Kaukonen, J. Hirvonen, M. Finel, The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells, Drug Metab. Disposition, 36 (2008) 2331-2336.

[1] M. Dong, B.R. LU, H.B. ZHANG, J.K. CHEN, B. Li, Role of sexual reproduction in the spread of an invasive clonal plant Solidago canadensis revealed using intersimple sequence repeat markers, Plant Species Biol., 21 (2006) 13-18.

 

© 2016 Pharmaceutical Sciences Laboratory

Offical University Website:

https://www.abo.fi/amnen/farmaci/

Pharmaceutical Sciences

Åbo Akademi University

BioCity 3rd floor

Artillerigatan 6A

FI 20520 Turku

Finland

  • LinkedIn Social Icon
  • Facebook Social Icon