Research group: Functional Materials for Medicine

Functional Materials have played more and more critical role in development of novel treatment methods for different diseases. Our group focus on designing all kinds of functional materials, at different scales, to solve clinical and biological problems. We have broad collaborations with hospitals, and most of our projects have clinical doctors involved and initial from a real-life clinical question. Our group is multidisciplinary,  which interplay between physics, materials science, synthetic organic chemistry, engineering, biology and medicine. We aim that many of our designs could be clinical applicable in future, and to have a great social impact in treating diseases. 


Principle Investigator

                                             Hongbo Zhang
                                             Hongbo Zhang received his bachelor´s                                                                                       degree in biology from Fudan University and PhD                                                                     degree in Pharmacy from University of Helsinki (2012)                                                             and did his Postdoc in Harvard University. In 2016, he                                                             was appointed as Tenure Track Associate Professor in                                                             Åbo Akademi University and he became Associate                                                                   Professor in 2018. He is Academy of Finland Postdoc                                                               Fellow between 2016-2019 and Research Fellow                                                                       between 2019-2024. He is also a docent in                                                                                 Pharmaceutical Technology in University of Helsinki. His research focus is functional materials in biomedical applications and their potential in clinical translations. 

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Senior Researchers

Xiaoyu Xu received her PhD degree in Chemistry from Tongji University in China (2013-2018) with the research field of lanthanide photo-functionalized metal-organic framework (MOF) hybrid materials. From April 2018, she started her postdoc research in Prof. Hongbo Zhang’s Lab, Pharmaceutical Sciences Laboratory at Åbo Akademi University. Her research focus is MOF-based biomaterials in biomedical application. Currently she is developing smart delivery systems based on MOFs biomineralization and applying them for CRISPR/Cas9-based gene therapy.

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Jixiang Wang received his PhD degree in Material Science from Jiangsu University in China. From August 2019, he started his postdoc research in Prof. Hongbo Zhang’s Lab, Pharmaceutical Sciences Laboratory at Åbo Akademi University. His research focus is Molecular Imprinting-based biomaterials in biomedical applications.

PhD Student

Chang Liu received his Master degree in Inorganic Chemistry from Tongji University in China (2016), then started his PhD studies in Prof. Hongbo Zhang’s group, Pharmaceutical sciences laboratory at Åbo Akademi university. His current research interests are in the design of functional nanomaterials, particularly MOFs-based biomimetic mineralized composites and their theranostic applications.

                                             Wenhui Zhou received his Bachelor and                                                       Master Degree in Medicine at Hubei                                                            University of Medicine and Southern Medical                                              University in China. He did his master                                                          diploma thesis at the Key Laboratory of                                                        Animal Models and Human Disease                                                              Mechanisms of the Chinese Academy of                                                      Sciences and Yunnan Province, Kunming                                                      institute of zoology, Chinese Academy of                                                    Sciences, China. He then worked in the area                                                of cancer cell biology for two years at the                                                    Hubei Key Laboratory of Embryonic Stem Cell                                              Research, Hubei University of Medicine, China. In Sep, 2019, He started his PhD in the field of nucleic acid drug delivery in the group of Prof. Hongbo Zhang in the Pharmacy, Faculty of Science and Engineering, Åbo Akademi University. The main work of him is focused on the development of in vitro transcribed messenger RNA intracellular delivery nano-platform for cancer therapy.

Jiaqi Yan received his Bachelor and Master Degree in Pharmaceutics at the Shenyang Pharmaceutical University and Guangdong phamaceutical University in China. He performed his master diploma thesis at pharmaceutical science laboratory, Åbo Akademi University, Finland. Afterwards he started his PhD in the field of DNA nanotechnology in the group of Prof. Hongbo Zhang in the Pharmacy, Faculty of Science and Engineering, Åbo Akademi University. His work is focused on the development of synthetic miRNA based therapeutic strategies for the cancer therapy.

Yu Chen is awarded his Bachelor's and Master's degrees in medicine from Anhui University of Science & technology and Bengbu Medical College, respectively. Currently, he is a PhD student in Åbo Akademi University, Finland. His supervisor is Prof. Hongbo Zhang from Department of Pharmacy, Faculty of Science and Engineering. Simultaneously, Prof. Wenguo Cui from Ruijin Hospital, Shanghai Jiao Tong University School of Medicine acts as his co-supervisor. His work is focused on the development of novel biomaterials and nanomaterials for tissue regeneration, drug delivery, and disease treatment.

                                             Dabao Shang received his bachelor degree in                                              clinical medicine from The Southern Medical                                                University in Guangzhou, China, and received                                              Master Degree at Shanghai Jiaotong                                                            University in clinical medicine in China.                                                         Afterwards he started his PhD in the field of                                                  Drug Development and Medical Technology

                                             in the group of Prof. Hongbo Zhang in the                                                    Pharmacy, Faculty of Science and                                                                  Engineering, Åbo Akademi University and the                                              group of Prof. Wenguo Cui in the Ruijin                                                        Hospital Affiliated to Shanghai Jiaotong                                                        University School of Medicine/Shanghai Institute of Traumatology and Orthopedics. His work is focused on the development of new drugs based therapeutic strategies for bone and joint repair and functional reconstruction based on biomedical materials.


Shengyi Wang received his bachelor and master degree in Jiangxi Science and Technology Normal University and Nanchang University in China. Then, he started working in EYE & Hospital of Fudan University and focus on gene editing and treatment for hereditary deafness.


Pengzhen Zhuang got his Bachelor and Master’s Degree from Anhui University of Technology and Wuhan University of Technology, respectively. Currently, he is starting his PhD studies in the group of Prof. Hongbo Zhang in Pharmaceutical Sciences Laboratory, Åbo Akademi University and he is co-supervised by Prof. Wenguo Cui at Ruijin Hospital, Shanghai Jiao Tong University School/Shanghai Institute of Traumatology and Orthopaedics. His work focuses on the development of inorganic nanomaterials related to bone repair.

Dhayakumar Rajan Prakash (D.K) received his bachelor degree in bioengineering and master degree in Medical Nano technology where he did his master thesis project at Pharmaceutical sciences laboratory at Åbo Akademi university. He then started to work with ChinFin innovation and incubation oy where it was supporting his PhD studies and from 2021 February he started working in Brinter oy as Bionic Engineer. His thesis research topic is focused on smart stimuli responsive material manipulation and manufacturing.

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Oliver Koivisto has received his bachelor and master degree in Physiology and Genetics at University of Turku in Finland. He completed his Master’s thesis in 2020 in Prof. Hongbo Zhang´s group at the Pharmaceutical science laboratory, Faculty of Science and Engineering at Åbo Akademi University. Currently, he is continuing the work with the group and aiming for a PhD. His work focuses on the CRISPR/Cas9 gene editing and in development of a new delivery system for cancer therapy.

Yonghui Wang received her Bachelor's and Master's Degree in Pharmaceutics at the Shenyang Pharmaceutical University and Shanghai Institute of Materia Medica, Chinese Academy of Sciences in China. In her master's degree, she was an interesting area in Functional Nanoparticles for Targeted Drug Delivery. Afterward, she started her Ph.D. in the field of molecular pharmaceutics in the group of Prof. Hongbo Zhang in the Pharmacy, Faculty of Science and Engineering, Åbo Akademi University. Her work focuses on disease-specific microenvironments and is based on the development of specific responsive vectors and the study of drug-body interactions.

Xiaodong Ma graduated from Jiangsu Ocean University, China, with a B.S. in Pharmaceutical Engineering and an M.S. in Marine Chemistry. He completed his master's thesis at the Pharmacy Laboratory of Åbo Akademi University, Finland. After that, he started his PhD research in the field of pro-drug nanotechnology in the group of Prof. Hongbo Zhang in the Department of Pharmacy, Faculty of Science and Engineering, Åbo Akademi University. His work focused on the synthesis of pro-drugs and their application in the field of disease treatment.

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Xiwen Geng received her Bachelor and Master Degree in Nanjing Agriculture University and Shandong University in China. From May 2021, she started her PhD studies in the group of Prof. Hongbo Zhang in Pharmaceutical Sciences Laboratory, Åbo Akademi University and she is co-supervised by Prof. Yuanjin Zhao in Nanjing Drum Tower Hospital, Nanjing University. Her work is focused on the development of therapeutic strategies against antimicrobial resistance based on biomedical materials.


Yu Zhang received his Bachelor and Master of Science degrees from Henan Normal University and Soochew University in China. Now, he is studying for a PhD in the group of Prof. Hongbo Zhang in the Pharmacy, Faculty of Science and Engineering, Åbo Akademi University. His main research direction is to develop new biomaterials to regulate the bone marrow immune microenvironment and promote bone regeneration.

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Meixin Ran received her bachelor and master degree in pharmaceutics at the Shenyang Pharmaceutical University in China. Afterwards she started her PhD in the field of novel technologies for gene delivery in the group of Prof. Hongbo Zhang in the Pharmacy, Faculty of Science and Engineering, Åbo Akademi University. Her work is focused on the development of miRNA-responsive nanogel for gene delivery.


Wu Yang is awarded his Bachelor's and Master's degrees in medicine from Guizhou Medical University and Chongqing Medical University, respectively. Afterwards he started his PhD in the field of Drug Development and Medical Technology in the group of Prof. Hongbo Zhang in the  Pharmacy, Faculty of Science and Engineering, Åbo Akademi University and the group of Prof. Wenguo Cui in the Ruijin Hospital Affiliated to Shanghai Jiaotong   University School of Medicine/ Shanghai Institute of Traumatology and Orthopedics. His work is try to regulate the bone regeneration using Gene Therapy.

Cosupervised PhD student

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Rawand A. Mustafa received his Bachelor in pharmacy and did  Master degree in Pharmaceutical sciences at the University of Central lancashire (UCLAN) in the United kingdom (UK). Afterwards, he started his PhD in the field of nanoparticle for drug delivery and biomedical application using miccrfluidics in the group of Prof. Hongbo Zhang in the Pharmacy, Faculty of Science and Engineering, Åbo Akademi University, Finland. His work is  focused on the development of silica core shell nanoparticles for different biomedical application systems.

Rui Liu received her bachelor degree in pharmaceutical engineering from Henan University of Traditional Chinese Medicine and received her master degree at Tianjin University of Science and Technology in chemical processing of forest products. Currently, she is a doctor student of chemical enginerring, working on the development of biomass derived functional nanomaterials to be used in biomecine under the supervision of Professor Chunlin Xu and professor Hongbo Zhang (co-supervisor) at Åbo Akademi University in Finland.


Prof. Sergej Filippov, Visiting Professor, Harvard University, USA (2019-2021)

Cassandre Rouanet, thesis worker, Institut Universitaire Technologique Génie Biologique of Laval/Erasmus, France (2021)​

Brajesh Shrestha, MSc thesis worker, ÅAU (2020-2021)

Assoc. Prof. Junnian Zhou, Visiting Professor, China (2019-2021)

Assoc. Prof. Yong Guo, Visiting Professor, China (2019-2021)

Assoc. Prof. Ye Liang, Visiting Professor, China (2019-2020)

Assoc. Prof. You Zhou, Visiting Scholar, China (2019-2020)

Dr. Yulong Han, Visiting Scholar, Harvard/MIT (2019-2020)

Tzu-Chen Rautio, MSc thesis worker, UTU (2019-2021)

Doroteja Bednjanec, MSc thesis worker, ÅAU (2019-2021)

Deependra Yadav, MSc thesis worker, UTU (2019-2021)

Dado Tokic, MSc thesis worker, UTU/Drug Disovery & Development (2019-2020)

Wanping He, Msc thesis worker, China (2018-2019)

Laura Leenesonne, MSc thesis worker, Ghent University/Erasmus, Belgium (2019)​

Ahmed Hassan Ibrahim, Department of Pharmaceutics and Industrial Pharmacy, Al-Azhar University, Egypt (2018-2019)

​​Abrar Taiseer, MSc thesis worker,  UTU/Drug Disovery & Development MSc programme (2018-2019)

Mariam Gouda, MSc thesis worker, UTU/Drug Disovery & Development MSc programme (2018-2019)

​Alexandra Manea, MSc thesis worker, UTU/Drug Disovery & Development MSc programme (2018-2019)

Associate Prof. Ming Ma, China (2018)

Associate Prof. Yuezhou Zhang, China (2016-2018)

Tanzeela Bashir, Intership, Oulu University (2018)

Rukiye Nur Akpolat, Intership, Turkey (2018)

Minghua Yao, Tongji University Affiliated Hospital, China (2018)

Korbinian Weisensee, MSc thesis worker, Germany (2017-2018)

Shahadat Hossain, Research Assistant (2017-2018)

Jing Tu, postdoc, the Netherlands/China (2017-2018)

Bram Bogaert, MSc thesis worker, Ghent, Belgium (2017)


2021 (20)

[124] Rui Liu, Annika Smeds, Luyao Wang, Andrey Pranovich, Jarl Hemming, Stefan Willfor, Hongbo Zhang*, Chunlin Xu*. "Fractionation of lignin with decreased heterogeneity: based on a detailed characteristics study of sequentially extracted softwood kraft lignin", ACS Sustainable Chemistry & Engineering, 2021, Accepted. (corresponding author) 

[123] Chang Liu, Xiaoyu Xu, Wenguo Cui, Hongbo Zhang*. "Metal-organic framework (MOF)-based biomaterials in bone tissue engineering", Engineered Regeneration, 2021, Accepted, Prospective, (corresponding author). 

[122] Chang Liu, Xiaoyu Xu, Oliver Koivisto, Wenhui Zhou, Guillaume Jacquemet, Jessica M. Rosenholm, and Hongbo Zhang*."Improving the Knock-In Efficiency of MOF-Encapsulated CRISPR/Cas9 System through Controllable Embedding Structures", Nanoscale, Accepted. (corresponding author) 

[121] Xiaobin Guo, Jiaxiang Bai, Gaoran Ge, Zhidong Wang, Qing Wang, Kai Zheng, Huaqiang Tao, Lirong Zhang, Hongbo Zhang, Dongqing Wang, Xiaogang Zhang, Hongxia Li, Guoqing Pan, Dechun Geng. "Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis", J. Colloid Interface Sci, 2021, 605, 410-424.

[120] Yuyang Tong, Peixuan Sun, Juanjuan Yong, Hongbo Zhang, Yunxia Huang, Yi Guo, Jinhua Yu, Shichong Zhou, Yulong Wang, Yu Wang, Qinghai Ji, Yuanyuan Wang, Cai Chang. "Radiogenomic Analysis of Papillary Thyroid Carcinoma for Prediction of Cervical Lymph Node Metastasis: A Preliminary Study", Front Oncol. 2021, Accepted.

[119] Xiaoyu Xu, Chang Liu, Yonghui Wang, Oliver Koivisto, Junnian Zhou, Yilai Shu, Hongbo Zhang*, "Nanotechnology-based Delivery of CRISPR/Cas9 for Cancer Treatment " Adv. Drug. Deliv. Rev. 2021., Accepted. (corresponding author)

[118] Yuezhou Zhang, Huaguang Cui, Ruiqi Zhang, Hongbo Zhang* and Wei Huang*, "Nanoparticulation of Prodrug into Medicines for Cancer Therapy", Adv. Sci. 2021, (Accepted) (corresponding author)

[117] Jiaqi Yan, Yichuan Wang, MeiXin Ran, Rawand A. Mustafa, Huanhuan Luo, Jixiang Wang, Jan-Henrik Smått, Jessica Rosenholm, Wenguo Cui, Yong Lu*, Zhenpeng Guan*, Hongbo Zhang*, "Peritumoral Microgel Reservoir for Long-term Light-controlled Trible-synergistic Treatment of Osteosarcoma with Single Ultra-low Dose", Small. 2021, (Accepted) (corresponding author)

[116] Lei Wu, Wenhui Zhou, Lihua Lin, Anhong Chen, Jing Feng, Xiangmeng Qu*, Hongbo Zhang*, and Jun Yue*, "Delivery of Therapeutic Oligonucleotides in Nanoscale", Bioact. Mater. 2021, (Accepted) (corresponding author)

[115] Zhen Wang, Yichuan Wang, Jiaqi Yan, Keshi Zhang, Feng Lin, Lei Xiang, Lianfu Deng, Zhenpeng Guan, Wenguo Cui, Hongbo Zhang, "Pharmaceutical Electrospinning and 3D printing scaffold design for bone regeneration", Adv. Drug. Deliv. Rev. 2021., 174,  504-534. (corresponding author)

[114] Wei Ji, Xiaodan Li, Mingshu Xiao, Yueyang Sun, Wei Lai, Hongbo Zhang, Hao Pei, and Li Li*, "DNA-Scaffolded Disulfide Redox Network for Programming Drug-Delivery Kinetics", Chem. Eur. J., 2021, 27, 1–9.

[113] Feng Zhang, Yiran Zhang, Li Kong, Huanhuan Luo, Yuezhou Zhang, Ermei Mäkilä, Jarno Salonen, Jouni T. Hirvonen, Yueqi Zhu, Yingsheng Cheng, Lianfu Deng, Hongbo Zhang*, Alexander Kros, Wenguo Cui*, Hélder A. Santos*, “Multistage Signal Interactive Nanoparticles Improves Tumor Targeting Through Efficient Nanoparticle-Cell Communications”, Cell Rep. 2021, 35,  109131 (corresponding author)

[112] Huanhuan Luo, Li Kong, Feng Zhang, Chenglong Huang, Jiayi Chen, Hongbo Zhang, Han Yu, Song Zheng, Hongwei Xu, Yiran Zhang, Lianfu Deng, Gang Chen*, Hélder A. Santos*, Wenguo Cui*, “Light-Controlled Nanosystem With Size Flexibility Improves Targeted Retention for Tumor Suppression”, Adv. Funct. Mater. 2021.

[111] Lu Chen, Liucheng Zhang, Hongbo Zhang, Xiaoming Sun, Dan Liu, Jianming Zhang, Yuguang Zhang*, Liying Cheng*, Hélder A. Santos*, Wenguo Cui*, “Programmable Immune Activating Electrospun Fibers for Skin Regeneration”, Bioact. Mater. 2021, 6 (10), 3218-3230(Co-first author)

[110] Jixing Wang, Lihua Zou, Jingjing Xu, Rong Zhang, Hongbo Zhang*. "Molecularly Imprinted Fluoroprobes Doped with Ag Nanoparticles for Highly Selective Detection of Oxytetracycline in Real Samples", Analytica Chimica Acta. 2021, 1161, 338326 (Coresponding author)

[109] Zhijie Chen, Feng Zhang, Hongbo Zhang, Liang Cheng, Kaizhe Chen, Jieliang Shen, Jin Qi, Lianfu Deng, Chuan He*, Hélder A. Santos*, Wenguo Cui*, “DNA-Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo-Controlled Osteoarthritis Gene Therapy”, Adv. Sci. 2021. (accepted) (Co-first author)

[108] Junnian Zhou, Tzu-Chen Rautio, Chang Liu, Xiaoyu Xu, Dongqing Wang, Yong Guo, John Eriksson, Hongbo Zhang*, "Delivery of Protein Kinase A by CRISPRMAX and Its Effects on Breast Cancer Stem-Like Properties", Pharmaceutics, 2021, 13(1), 11. (Corresponding author).

[107] Xu Zhang*, Hongbo Zhang, Jianmei Gu, Jiayin Zhang, Hui Shi, Hui Qian, Dongqing Wang, Wenrong Xu, Jianming Pan*, Hélder A. Santos*, “Engineered Extracellular Vesicles for Cancer Therapy”, Adv. Mater. 2021, 33(14) e2005709. (Co-first author)

[106] Qiaolin Wei, Hamed Arami,, Hélder A. Santos, Hongbo Zhang, Yangyang Li,, Jian He, Danni Zhong, Daishun Ling, Min Zhou. "Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles", Adv. Sci. 2021, 8(5), 2002788.  (Co-first author).

[105] Ye Liang, Yonghua Wang, Liping Wang, Zhijuan Liang, Dan Li, Xiaoyu Xu, Yuanbin Chen, Xuecheng Yang*, Hongbo Zhang*, HaitaoNiu*. "Self-crosslinkable Chitosan-Hyaluronic Acid Dialdehyde Nanoparticles for CD44-targeted siRNA Delivery to Treat Bladder Cancer". Bioactive Materials, 2020,  6 (2), 433-446  (corresponding author).

2020 (21) 

[104] Jingyan Gao, Xiaodong Ma, Lirong Zhang, Jiaqi Yan, Huaguang Cui, Yuezhou Zhang, Dongqing Wang, Hongbo Zhang*, "Self-assembled Disulfide Bond Bearing Paclitaxel- Camptothecin Prodrug Nanoparticle for Lung Cancer Therapy", Pharmaceutics, 2020 12(12), 1169 (Corresponding author).

[103] Jie Shen, Ming Ma, Hongbo Zhang, Huizhu Yu, Fengfeng Xue, Nanjing Hao, Hangrong Chen. "Microfluidics-Assisted Surface Tri-Functionalization of Zeolitic Imidazolate Framework Nanocarrier for Targeted and Controllable Multitherapies of Tumor".  ACS Appl. Mater. Interfaces. 2020, 12, 41, 45838–45849

[102] Ruoyu Cheng, Flavia Fontana, Junyuan Xiao, Zehua Liu, Patrícia Figueiredo, Mohammad-Ali Shahbazi, Shiqi Wang, Jing Jin, Giulia Torrieri, Jouni T. Hirvonen, Hongbo Zhang, Tongtong Chen, Wenguo Cui*, Yong Lu*, Hélder A. Santos*, “Recombination Monophosphoryl Lipid A Derived Vacosome for the Development of Preventive Cancer Vaccines”, ACS Appl. Mater. Interfaces. 2020, 12, 40, 44554–44562

[101] Kun Zhang, Xiaoting Cheng, Liping Zhao, Mingqian Huang, Yong Tao, Hongbo Zhang, Jessica M Rosenholm, Min Zhuang, Zheng-Yi Chen, Bing Chen, Yilai Shu. "Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear In Vivo", Molecular Therapy-Methods & Clinical Development, 2020, 18, 511-519.

[100] Minghua Yao, Xiaojing Shi, Changjing Zuo, Ming Ma,* Lu Zhang, Hongbo Zhang, Xin Li, Guo-Yuan Yang, Yaohui Tang,* Rong Wu.* "Engineering of SPECT/Photoacoustic Imaging/Antioxidative-Stress Triple-Function Nanoprobe for Advanced Mesenchymal Stem Cell Therapy of Cerebral Ischemia".  ACS Appl. Mater. Interfaces 2020, 12 (34), 37885-37895.

[99] Guicai Li, Qi Han, Liling Zhang, Panjian Lu, Yuezhou Zhang, Shiyu Chen, Ping Zhang, Luzhong Zhang, Wenguo Cui, Hongkui Wang, Hongbo Zhang*. "Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration". Research 2020,  (corresponding author).

[98] Jiaqi Yan, Chang Liu, Qiwei Wu, Junnian Zhou, Xiaoyu Xu, Lirong Zhang, Dongqing Wang, Fan Yang, Hongbo Zhang*. "Mineralization of pH sensitive Doxorubicin Prodrug in ZIF-8 to Enable the Target Delivery to Solid Tumors" Analytical Chemistry, 2020, 92 (16), 11453-11461.  (corresponding author).

[97] Amit Kumar Rajora,* Divyashree RavishankarHongbo Zhang, Jessica M. Rosenholm. "Recent advances and impact of nanoformulations of chemo- and antiangiogenesis for combination cancer therapy". Pharmaceutics 2020, 12(6), 592;

[96] Emilia Palo, Hongbo Zhang, Mika Lastusaari, Mikko Oskari Salomäki.  "Nanometer-Thick Ion-Selective Polyelectrolyte Multilayer Coatings to Inhibit the Disintegration of Inorganic Upconverting Nanoparticles" ​ACS Appl. Nano Mater. 2020​, 3 (7), 6892-6898.

[95] Yang Ye, Jian He, Yue Qiao, Yuchen Qi, Hongbo Zhang, Hélder A. Santos, Danni Zhong, Wanlin Li, Shiyuan Hua, Wei Wang, Andrzej Grzybowski, Ke Yao*, Min Zhou*, “Mild Temperature Photothermal Assisted Anti-Bacterial and Anti-Inflammatory Nanosystem for Synergistic Treatment of Post-Cataract Surgery Endophthalmitis”, Theranostics 2020, 10(19), 8541-8557.

[94] Chang Liu; Xiaoyu Xu; Junnian Zhou; Jiaqi Yan; Dongqing Wang; Hongbo Zhang*. "Redox-responsive Tumor Targeted Dual-drug Loaded Biocompatible Metal-organic Frameworks Nanoparticles for Enhancing Anticancer Effects", BMC Mater. 2020 2 (1), 1-11.  (corresponding author).

[93] Xiaoyu Xu; Oliver Koivisto; Chang Liu; Daqi Wang; Junnian Zhou; Mitro Miihkinen; Guillaume Jacquemet; Jessica Rosenholm*; Yilai Shu*; Hongbo Zhang*.  "Effective delivery of the CRISPR/Cas9 system enabled by functionalized mesoporous silica nanoparticles for GFP-tagged paxillin knock-in", Adv Ther, 2020,

[92] Kawthar Mohamed, Eduardo Rodríguez-Román, Farzaneh Rahmani, Hongbo Zhang, Mariya Ivanovska, Sara A. Makka, Musa Joya, Rangarirai Makuku, Md Shahidul Islam, Nesrine Radwan, Laila Rahmah, Rayan Goda, Sunny O. Abarikwu, Mujtaba Shaw, Samaneh Zoghi, Sevan Irtsyan , Irene Ling, Orsolya Cseprekal, Attig-Bahar Faten, Esra Hazar Sayar, Chagajeg Soloukey, Giulia Grancini, Nima Rezaei. International Efforts to Save Healthcare Personnel during COVID-19. Acta Biomedica Atenei Parmensis, 2020, 3/20 (September) , COVID-19 UPDATE section. 

[91] Yunzhan Li, Zehua Liu, Li Li, Wenhua Lian, Yaohui He, Elbadry Khalil, Ermei Mäkilä, Wenzhong Zhang, Giulia Torrieri, Xueyan Liu, Jingyi Su, Yuanming Xiu, Flavia Fontana, Jarno Salonen, Jouni Hirvonen, Wen Liu, Hongbo Zhang*, Hélder A. Santos*, Xianming Deng*, “Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses Under Diseased Condition”, Adv. Sci. 2020. 7 (15), 2001129

[90] Kawthar Mohamed, Eduardo Rodríguez-Román, Farzaneh Rahmani, Hongbo Zhang, Mariya Ivanovska, Sara A. Makka, Musa Joya, Rangarirai Makuku, Md Shahidul Islam, Nesrine Radwan, Laila Rahmah, Rayan Goda, Sunny O. Abarikwu, Mujtaba Shaw, Samaneh Zoghi, Sevan Irtsyan, Irene Ling, Orsolya Cseprekal, Attig-Bahar Faten, Esra Hazar, Chagajeg Soloukey Tbalvandany, Giulia Grancini, Nima Rezaei, "Borderless collaboration is needed for COVID-19; a disease that knows no borders", Infection Control & Hospital Epidemiology, 2020, 1-7

[89] Liucheng Zhang, Yi Xiang, Hongbo Zhang, Liying Cheng, Xiyuan Mao, Ning An, Lu Zhang, Jinxiong Zhou, Lianfu Deng, Yuguang Zhang*, Xiaoming Sun*, Hélder A. Santos*, Wenguo Cui*, “Biomimetic 3D-Self-Forming Approach For Microvascular Scaffolds”, Adv. Sci. 2020, 7, 1903553 (Co-first author)

[88] Jiaqi Yan, Xiaoyu Xu, Junnian Zhou, Chang Liu, Lirong Zhang, Dongqing Wang, Fan Yang, Hongbo Zhang*, ” Fabrication of a pH/redox-triggered mesoporous silica-based nanoparticle with microfluidics for anti-cancer drugs doxorubicin and paclitaxel co-delivery”, ACS Applied Bio Materials, 2020, 3, 2, 1216–1225 (corresponding author).

[87] Jian He, Yue Qiao, Hongbo Zhang, Jun Zhao,Wanli Li, Tingting Xie, Danni Zhong, Qiaolin Wei, Shiyuan Hua, Yinhui Yu, Ke Yao, Hélder A. Santos*, Min Zhou*, “Gold-Silver Nanoshells Promote Wound Healing from Drug-Resistant Bacteria Infection and Enable Monitoring via Surface-Enhanced Raman Scattering Imaging”, Biomaterials 2020, 234, 119763. (Co-first author)

[86] Guohong Cao, Yangyang Li, Yucheng Qi, Yue Qiao, Jian He, Hongbo Zhang*, Wenguo Cui*, Min Zhou*, "NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices", Mater. Today. Adv. 2020, 6, 100044

 (Corresponding author).

[85] Ruoyu Cheng, Lili Liu, Yi Xiang, Yong Lu, Lianfu Deng, Hongbo Zhang*, Hélder A. Santos*, Wenguo Cui*, “Advanced Liposome-Loaded Scaffolds for Therapeutic and Tissue Engineering Applications”, Biomaterials 2020, 232, 119706. (Corresponding author)

[84] Yusen Qiao, Xingzhi Liu, Xichao Zhou, Hongbo Zhang, Wen Zhang, Wei Xiao, Guoqing Pan, Wenguo Cui*, Hélder A. Santos*, Qin Shi*, “Gelatin Templated Polypeptide Co-crosslinked Hydrogel for Bone Regeneration”, Adv. Healthcare Mater. 2020, 9(1), 1901239. (Co-first author)

2019 (18)

[83Guicai Li, Xueying Zhao, Luzhong Zhang, Jian Yang, Wenguo Cui, Yumin Yang, Hongbo Zhang*. “Anisotropic ridge/groove microstructure for regulating morphology and biological function of Schwann cells”, Applied Materials Today, 2019, 18, 100468 (Corresponding author)

[82] Yimin Wang, Di Wu, Guohua Wu, Jianguo Wu, Siming Lu, James Lo, Yong He, Chao Zhao, Xin Zhao, Hongbo Zhang, ShuQi Wang. "Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy". Theranostics 2019, 10 (1), 300

[81] Yangyang Li, Yuchen Qi, Hongbo Zhang, Zhiming Xia, Tingting Xie, Wanlin Li, Danni Zhong, Huanle Zhu, Min Zhou, "Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostics", Biomaterials, 2019, 119538 (Co-first author)

[80] Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang*, Hélder A. Santos*, Hongxing Shen*, “Gene-Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus”, Adv. Sci. 2020, 7(1), 1902099.

[79Jincheng Tang, Yong Gu, Hongbo Zhang, Liang Wu, Yun Xu, Jiannan Mao, Tianwen Xin, Tingjun Ye, Lianfu Deng, Wenguo Cui*, Hélder A. Santos*, Liang Chen*, “Outer-Inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis”, Nanoscale 2019, 11, 15794–15803. (Co-first author)

[78] Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu, Lu Gan*, Hélder A. Santos*, Xiangliang Yang*, “Tumor Exosome-Based Nanoparticles are Efficient Drug Carriers for Chemotherapy”, Nature Commun. 2019, 10(1), 3838. (Co-first author)

[77] Diosangeles Soto Veliz*, Hongbo Zhang, Martti Toivakka. "Stacking up: a new approach for cell culture studies".  Biomaterials Science, 2019. 7 (8), 3249-3257

[76]  Ranjith Kumar Kankala, Hongbo Zhang, Chen-Guang Liu, Kiran Reddy Kanubaddi, Chia-Hung Lee, Shi-Bin Wang, Wenguo Cui*, Hélder A. Santos*, KaiLi Lin*, Ai-Zheng Chen*, “Metal Species-Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs”, Adv. Funct. Mater. 2019, 29(43), 1902652. (Review) (Co-first author)

[75]  Yue Qiao, Yuan Ping, Hongbo Zhang, Fengyong Liu, Bo Zhou, Yinhui Yu, Tingting Xie, Wanli Li, Danni Zhong, Yuezhou Zhang, Ke Yao, Hélder A. Santos*, Min Zhou*, “Laser Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Wound Healing for Infected Chronic Nonhealing Wounds”, ACS Appl. Mater. Interfaces 2019, 11(4), 3809–3822. (Co-first author)

[74]  Hongbo Zhang, Wenguo Cui, Xiangmeng Qu, Huayin Wu, Liangliang Qu, Xu Zhang, Ermei Mäkilä, Jarno Salonen, Yue-Qi Zhu*, Zhou Yang, Dong Chen, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Photothermal Responsive Nanosized Hybrid Polymersome as Versatile Therapeutics Co-Delivery Nanovehicle for Effective Tumor Suppression”, Proc. Natl. Acad. Sci. U.S.A. 2019, 116(16) 7744–7749.

[73] Xiaodong Ma,  Ezgi Ozliseli,  Yuezhou Zhang,  Guoqing Pan,  Dongqing WangHongbo Zhang*. ​"Fabrication of Redox- Responsive Doxorubicin and Paclitaxel Prodrug Nanoparticles with Microfluidics for Selective Cancer Therapy". Biomaterials Science, 2019. 7 (2), 634-644 (Corresponding author)

[72] Yufei Yan, Hao Chen, Hongbo Zhang, Changjun Guo, Kai Yang, Kaizhe Chen, Ruoyu Cheng, Niandong Qian, Niklas Sandler, Yu Shrike Zhang, Haokai Shen, Jin Qi, Wenguo Cui, Lianfu Deng. Vascularized 3D printed scaffolds for promoting bone regeneration. Biomaterials, 2018, 190, 97-110 (Co-first author)

[71]  Zehua Liu, Yunzhan Li, Wei Li*, Wenhua Lian, Marianna Kemell, Sami Hietala, Patrícia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang*, Xianming Deng*, Hélder A. Santos*, “Close-loop Dynamic Nanohybrids on Collagen-Ark with In-situ Gelling Transformation Capability for Bio-mimetically Stage Specific Diabetic Wound Healing”, Mater. Horiz. 2019, 6, 385–393. (Corresponding author)

[70]  Yufei Yan, Tao Sun, Hongbo Zhang, Xiuling Ji, Yulong Sun, Xin Zhao, Lianfu Deng, Jin Qi*, Wenguo Cui*, Hélder A. Santos*, Hongyu Zhang*, “Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis”, Adv. Funct. Mater. 2019, 29(4), 1807559. (Co-first author)

[69] Yuezhou Zhang, Dongfei Liu, Hongbo Zhang*, Hélder A. Santos,* "Chapter 7: Microfluidic Mixing and Devices for Preparing Nanoparticulate Drug Delivery Systems". In: Microfluidics for pharmaceutical applications: from nano/micro systems fabrication to controlled drug delivery, Santos H. A., Liu D., and Zhang H. (Eds.), Elsevier B.V. 2019, 155–177. (Corresponding author)

[68]  Shengcai Qi, Pengfei Zhang, Ming Ma*, Minghua Yao, Jinjin Wu, Ermei Mäkilä, Jarno Salonen, Heikki Ruskoaho, Yuanzhi Xu, Hélder A. Santos*, Hongbo Zhang*, “Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells”, Small 2019, 15(1), 1804332. (Corresponding author)

[67] Xiyuan Mao, Ruoyu Cheng, Hongbo Zhang, Jinhong Bae, Liying Cheng, Lu Zhang, Lianfu Deng, Wenguo Cui*, Yuguang Zhang*, Hélder A. Santos*, Xiaoming Sun*, "Self-Healing and Injectable Hydrogel for Matching Skin Flap Regeneration”, Adv. Sci. 2019, 6(13), 1901124. (Co-first author)

[66] Yueqi Zhu, Hongbo Zhang, Yiran Zhang, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng*, Minghua Li*, Hélder A. Santos*, Wenguo Cui*, “Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases”, Adv. Mater. 2019, 31(8), 1805452. (Co-first author)

2018 (17) 

[65] Xiaobin Guo, Yu Liu, Jiaxiang Bai, Binqing Yu, Menglei XuHouyi Sun, Jining Shen, Jiayi Lin, Hongbo ZhangDongqing WangDechun Geng, Guoqing Pan, "Efficient Inhibition of Wear‐Debris‐Induced Osteolysis by Surface Biomimetic Engineering of Titanium Implant with a Mussel‐Derived Integrin‐Targeting Peptide", Advanced Biosystems, 2018, 3(2),1800253

[64] Minghua Yao, Ming Ma*, Hongbo Zhang, Gang Wan, Yuezhou Zhang, Hangrong Chen*, Rong Wu*, “Theranostic Role of Cobalt Protoporphyrin Nano-Formulation for Photoacoustic Imaging Guided Stem Cell Implantation”. Adv. Funct. Mater. 2018. 28(47), 1804497

[63]  Wei Li, Yunzhan Li, Zehua Liu, Nattha Kerdsakundee, Ming Zhang, Feng Zhang, Xueyan Liu, Tomás Bauleth-Ramos, Wenhua Lian, Ermei Mäkilä, Marianna Kemell, Yaping Ding, Bruno Sarmento, Ruedeekorn Wiwattanapatapee, Jarno Salonen, Hongbo Zhang, Jouni T. Hirvonen, Dongfei Liu*, Xianming Deng*, Hélder A. Santos*, “Hierarchical Structured and Programmed Vehicles Deliver Drugs Locally to Inflamed Sites of Intestine”, Biomaterials 2018, 185, 322-332.

[62] Xingzhi Liu, Hongbo Zhang, Ruoyu Cheng, Yanzheng Gu, Yin Yin, Zhiyong Sun, Guoqing Pan, Zhongbin Deng, Huilin Yang, Lianfu Deng, Wenguo Cui*,  Hélder A Santos*, Qin Shi*, “An immunological Electrospun Scaffold for Tumor Imprison Killing and Healthy Tissue Regeneration”, Mater. Horiz. 2018, 5, 1082-1091. (Co-first author)

[61] Xiaoming Sun, Hongbo Zhang, Jinlin He, Ruoyu Cheng, Youwen Cao, Kunming Che, Liying Cheng, Lu Zhang, Guoqing Pan, Peihong Ni, Lianfu Deng, Yuguang Zhang*, Hélder A. Santos*, Wenguo Cui*, “Adjustable hardness of hydrogel for promoting vascularization and maintaining stemness of stem cells in skin flap regeneration”, Appl. Mater. Today 2018, 13, 54-63. (Co-first author)

[60]  Guanggai Xia, Hongbo Zhang, Ruoyu Cheng, Hongcheng Wang, Ziliang Song, Lianfu Deng, Xinyu Huang*, Hélder A. Santos*, Wenguo Cui*, “Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence”, Adv. Healthcare Mater. 2018, 7(18), 1800593. (Co-first author)

[59]  Dongfei Liu*, Katriina Lipponen, Peng Quan, Xiaocao Wan, Hongbo Zhang, Ermei M. Mäkilä, Jarno J. Salonen, Risto Kostiainen, Jouni J. Hirvonen, Tapio Kotiaho, Hélder A. Santos*, “Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions”, ACS Biomater. Sci. Eng. 2018, 4(7), 2308–2313.

[58] Book editing: Microfluidics for Pharmaceutical Applications, 560 pages, ISBN 9780128126592 .  

[57] Jianfeng Ji, Fei Ma, Hongbo Zhang, Fengyong Liu, Jian He, Wanlin Li, Tingting Xie, Danni Zhong, Tingting Zhang, Mei Tian*, Hong Zhang*, Hélder A. Santos*, Min Zhou*, “Light-Activatable Assembled Nanoparticles to Improve Tumor-Penetration and Eradicate Metastasis in Triple Negative Breast Cancer”, Adv. Funct. Mater. 2018, 28(33), 1801738. (Co-first author)

[56] Feng Zhang, Li Kong, Dongfei Liu, Wei Li, Ermei Mäkilä, Alexandra Correia, Rici Lindgren, Jarno Salonen, Jouni T. Hirvonen, Hongbo Zhang, Alexander Kros, Hélder A. Santos*, “Sequential Antifouling Surface for Efficient Modulation of the Nanoparticle-Cell Interactions in Protein-Rich Environment”, Adv. Ther. 2018, 1(1), 1800013.

[55] Ruibo Zhong, Qian Tang, Shaopeng Wang, Hongbo Zhang, Feng Zhang, Mingshu Xiao, Tiantian Man, Xiangmeng Qu, Li Li, Weijia Zhang, Hao Pei.* “Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors”. Advanced Materials 2018. 30(12), 1706887.

[54] Vimalkumar Balasubramanian, Andrea Poillucci, Alexandra Correia, Hongbo Zhang, Christian Celia,* Hélder A. Santos*, “Cell Membranes based Nanoreactor to Mimic the Bio-Compartmentalization Strategy of a Cell”, ACS Biomater. Sci. Eng. 2018, 4(4), 1471–1478.

[53] Hongbo Zhang, Yueqi Zhu, Liangliang Qu, Huayin Wu, Haixin Kong, Zhou Yang, Dong Chen, Ermei Makila, Jarno J. Salonen, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates”, Nano Lett. 2018, 18(2), 1448–1453.

[52] Yuezhou Zhang, Jing Tu, Dongqing Wang, Haitao Zhu, Sajal Kumar Maity, Xiangmeng Qu, Bram Bogaert, Hao Pei, Hongbo Zhang*. Programmable and Multifunctional DNA-Based Materials for Biomedical Applications. Advanced Materials, 2018 30(24), 1703658 (Corresponding author)

[51] Zehua Liu, Yunzhan Li, Wei Li, Chen Xiao, Dongfei Liu, Chao Dong, Ming Zhang, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni T. Hirvonen, Hongbo Zhang*, Dawang Zhou*, Xianming Deng*, Hélder A. Santos*, “Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics”, Adv. Mater. 2018, 30(24), 1703393. (Corresponding author)

[50] Zoran Cenev, Hongbo Zhang*, Veikko Sariola, Antti Rahikkala, Dongfei Liu, Hélder A. Santos*, Quan Zhou*, “Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle”, Adv. Mater. Technol. 2018, 3(1), 1700177. (Corresponding author)

[49] Dongfei Liu*, Hongbo Zhang, Flavia Fontana, Jouni T. Hirvonen, Hélder A. Santos*, “Current Developments and Applications of Microfluidic Technology Toward Clinical Translation of Nanomedicines”, Adv. Drug Deliv. Rev. 2018, 128, 54–83. (Invited Review)

​2017 (17)

[48] Xiangmeng Qu, Min Li, Hongbo Zhang, Chenglie Lin, Fei Wang, Mingshu Xiao, Yi Zhou, Jiye Shi, Ali Aldalbahi, Hao Pei, Hong Chen, Li Li. Real-Time Continuous Identification of Greenhouse Plant Pathogens Based on Recyclable Microfluidic Bioassay System. ACS Applied Materials & Interfaces 2017, 9 (37), pp 31568–31575

[47] Hongbo Zhang*, Dongfei Liu, Liang Wang, Zehua Liu, Runrun Wu, Agne Janoniene, Ming Ma, Guoqing Pan, Lina Baranauskiene, Linlin Zhang, Wenguo Cui, Vilma Petrikaite, Daumantas Matulis, Hongxia Zhao, Jianming Pan*, Hélder A. Santos*, “Microfluidic Encapsulation of Prickly Zinc-doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy”, Adv. Healthcare Mater. 2017, 6(11), 1601406.

[46] Tomás Bauleth-Ramos, Mohammad-Ali Shahbazi*, Dongfei Liu, Flavia Fontana, Alexandra Correia, Patrícia Figueiredo, Hongbo Zhang, João Pedro Martins, Jouni T. Hirvonen, Pedro Granja, Bruno Sarmento*, Hélder A. Santos*, “Nutlin-3a and Cytokine co-loaded Spermine-modified Acetalated Dextran Nanoparticles for Cancer Chemo-immunotherapy”, Adv. Funct. Mater. 2017, 27(42), 1703303. 

[45] Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi MH Salo‐Ahen, Ronald Österbacka, John E Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler, Tailored approaches in drug development and diagnostics – from molecular design to biological model systems(Review). Advanced Healthcare Materials, 2017, 6, 1700258

[44] Henni Auvinen, Hongbo Zhang, Nonappa, Alisa Kopilow, Elina H. Niemelä, Sami Nummelin, Alexandra Correia, Hélder A. Santos, Veikko Linko*, Mauri A. Kostiainen*, “Protein Coating of DNA Nanostructures for Enhanced Delivery, Stability and Immunocompatibility”, Adv. Healthcare Mater. 2017, 6(18), 1700692.

[43] Xiangmeng Qu, Fan YangHong ChenJiang LiHongbo ZhangGuo-Jun ZhangLi Li, Lihua Wang, Shiping SongYang Tian, and Hao Pei*. "Bubble-Mediated Ultrasensitive Multiplex Detection of Metal Ions in Three-Dimensional DNA Nanostructure-Encoded Microchannels". ACS Appl. Mater. Interfaces 2017. 9 (19), 16026-16034

[42] Agne Janoniene, Zehua Liu, Lina Baranauskiene, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni Hirvonen, Honbgo Zhang*, Vilma Petrikaite*, Hélder A. Santos*, “A Versatile Carbonic Anhydrase IX Targeting Ligand Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging”, ACS Appl. Mater. Interfaces 2017, 9(16), 13976–13987.

[41] Elisa Ollikainen, Dongfei Liu, Arttu Kallio, Ermei Mäkilä, Hongbo Zhang, Jarno Salonen, Hélder A. Santos, Tiina Sikanen*, “The Impact of Porous Silicon Nanoparticles on Human Cytochrome P450 Metabolism in Human Liver Microsomes In Vitro”, Eur. J. Pharm. Sci. 2017, 104, 124–132.

[40] Hongbo Zhang, Xiangmeng Qu, Hong Chen, Ruihua Ding, Dong Chen, Weixia Zhang, Xu Zhang, Hao Pei, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Fabrication of Calcium Phosphate-based Nanocomposites Containing DNA Origami, Gold nanorods and Drugs for Synergistic Anticancer Applications”, Adv. Healthcare Mater. 2017, 6(20), 1700664.

[39] Feng Zhang, Alexandra Correia, Ermei M. Mäkilä, Wei Li, Jarno J. Salonen, Jouni Hirvonen, Hongbo Zhang*, Hélder A. Santos*, “Receptor-Mediated Surface Charge Inversion Platform Based on Porous Silicon Nanoparticles for Efficient Cancer Cell Recognition and Combination Therapy”, ACS Appl. Mater. Interfaces 2017, 9(11), 10034–10046. (Corresponding author)

[38] Xiaoming Sun, Qi Lang, Hongbo Zhang, Liying Cheng, Ying Zhang, Guoqing Pan, Xin Zhao, Huilin Yang, Yuguang Zhang*, Hélder A. Santos*, Wenguo Cui*, “Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid in Vivo Vascularized Skin Flap Regeneration”, Adv. Funct. Mater. 2017, 27(2), 1604617. (Co-first author)

[37] Xiangmeng Qu, Hongbo Zhang, Hong Chen, Ali Aldalbahi, Li Li, Yang Tian, David A Weitz, Hao Pei*, Convection-Driven Pull-Down Assays in Nanoliter Droplets Using Scaffolded Aptamers, Anal. Chem., 2017,6, 3468-3473

[36] Dongfei Liu*, Hongbo Zhang, Salvatore Cito, Jin Fan, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Tiina M. Sikanen, David A. Weitz, Hélder A. Santos*, “Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation”, Nano Lett. 2017, 17(2), 606–614.

[35] Wei Li, Dongfei Liu, Hongbo Zhang, Alexandra Correia, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos, Hélder A. Santos*, “Microfluidic Assembly of a Nano-in-Micro Dual Drug Delivery Platform Composed of Halloysite Nanotubes and a pH-Responsive Polymer for Colon Cancer Therapy”, Acta Biomater. 2017, 48, 238–246.

[34] Bárbara Herranz-Blanco, Eloy Ginestar, Hongbo Zhang, Jouni Hirvonen, Hélder A. Santos*, “Microfluidics Platform for Glass Capillaries and its Application in Droplet and Nanoparticle Fabrication”, Int. J. Pharm. 2017, 516(1-2), 100–105.

[33] Lizhen Chen, Jie Chao, Xiangmeng Qu, Hongbo Zhang, Dan Zhu, Shao Su, Ali Aldalbahi, Lianhui Wang, Hao Pei*, Probing Cellular Molecules with PolyA-Based Engineered Aptamer Nanobeacon, ACS Appl. Mater. Interfaces, 9 (2017) 8014-8020.

[32] Vimalkumar Balasubramanian*, Alexandra Correia, Hongbo Zhang, Flavia Fontana, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos*, “Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-like Functions”, Adv. Mater. 2017, 29(11), 1605375.

2016 (10)

[31] Runrun Wu, Hongbo Zhang, Jianming Pan,* Hengjia Zhu, Yue Ma, Wenguo Cui, Hélder A. Santos*, Guoqing Pan*, “Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing”, Adv. Mater. Interfaces 2016, 3(18), 1600472. (Co-first author)

[30] Ari Ora, Erika Järvihaavisto, Hongbo Zhang, Henni Auvinen, Hélder A. Santos, Mauri A. Kostiainen*, Veikko Linko*, “Cellular Delivery of Enzyme-Loaded DNA Origami”, Chem. Commun. 2016, 52(98), 14161–14164.

[29] Zehua Liu, Vimalkumar Balasubramanian, Chinmay Bhat, Mikko Vahermo, Ermei Mäkilä, Marianna Kemell, Flavia Fontana, Agne Janoniene, Vilma Petrikaite, Jarno Salonen, Jari Yli-Kauhaluoma, Jouni Hirvonen, Hongbo Zhang*, Hélder A. Santos*, “Quercetin-based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells”, Adv. Healthcare Mater. 2017, 6(3), 1601009. (Corresponding author)

[28] Dongfei Liu, Tao Jiang, Weihua Cai, Jian Chen, Hongbo Zhang, Sami Hietala, Hélder A. Santos*, Guoyong Yin*, Jin Fan*, “An In Situ Gelling Drug Delivery System For Improved Recovery After Spinal Cord Injury”, Adv. Healthcare Mater. 2016, 5(12), 1513–1521.

[27] Feng Kong, Hongbo Zhang, Xu Zhang, Dongfei Liu, Dong Chen, Weixia Zhang, Liyuan Zhang, Hélder A. Santos, Mingtan Hai*, “Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications”, Adv. Funct. Mater. 2016, 26(34), 6158–6169. (Co-first author)

[26] Feng Kong, Hongbo Zhang, Xiangmeng Qu, Xu Zhang, Dong Chen, Ermei Mäkilä, Jarno Salonen, Hélder A. Santos, Mingtan Hai*, “Gold Nanorods, DNA Origami and Porous Silicon Nanoparticles Functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy”, Adv. Mater. 2016, 28(46), 10195–10203. (Co-first author)

[25] Hui Guo, Dongmei Liu, Bin Gao, Xiaohui Zhang, Minli You, Hui Ren, Hongbo Zhang, Hélder A. Santos, Feng Xu*, “Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine based on 3D Tumour Models”, Molecules 2016, 21(7), 954.

[24] F. Fontana, M.A. Shahbazi, D. Liu, H. Zhang, E. Mäkilä, J. Salonen, J.T. Hirvonen, H.A. Santos*, Multistaged Nanovaccines Based on Porous Silicon@ Acetalated Dextran@ Cancer Cell Membrane for Cancer Immunotherapy, Adv. Mater., (2016).

[23] Mónica P. A. Ferreira*, Sanjeev Ranjan, Alexandra M. R. Correia, Ermei M. Mäkilä, Sini M. Kinnunen, Hongbo Zhang, Mohammad-Ali Shahbazi, Patrick V. Almeida, Jarno J. Salonen, Heikki J. Ruskoaho, Anu J. Airaksinen, Jouni T. Hirvonen*, Hélder A. Santos*, “In Vitro and In Vivo Assessment of Heart-Homing Porous Silicon Nanoparticles”, Biomaterials 2016, 94, 93–104.

[22] Hao Chen, Peng Jia, Hui Kang, Hongbo Zhang, Yi Liu, Peilang Yang, Yufei Yan, Guilai Zuo, Lei Guo, Min Jiang, Jin Qi, Yuanyuan Liu*, Wenguo Cui*, Hélder A. Santos*, Lianfu Deng.* , “Up-Regulating Hif-1a by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound”, Adv. Healthcare Mater. 2016, 5(8), 907–918.

2015 (5)

[21] R. Vasiliauskas, D. Liu, S. Cito, H. Zhang, M.-A. Shahbazi, T. Sikanen, L. Mazutis, H.A. Santos*, Simple microfluidic approach to fabricate monodisperse hollow microparticles for multidrug delivery, ACS Appl. Mater. Inter., 7 (2015) 14822-14832.

[20] S. Näkki, J. Rytkönen, T. Nissinen, C. Florea, J. Riikonen, P. Ek, H. Zhang, H.A. Santos, A. Närvänen, W. Xu*, Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration, Acta Biomater., 13 (2015) 207-215.

[19] D.F. Liu*, H.B. Zhang, E. Mäkilä, J. Fan, B. Herranz-Blanco, C.F. Wang, R. Rosa, A.J. Ribeiro, J. Salonen, J. Hirvonen, H.A. Santos*, Microfluidic assisted one-step fabrication of porous silicon@acetalated dextran nanocomposites for precisely controlled combination chemotherapy, Biomaterials, 39 (2015) 249-259.

[18] F. Kong#, X. Zhang#, H. Zhang#, X. Qu, D. Chen, M. Servos, E. Mäkilä, J. Salonen, H.A. Santos, M. Hai, Inhibition of Multidrug Resistance of Cancer Cells by Co‐Delivery of DNA Nanostructures and Drugs Using Porous Silicon Nanoparticles@ Giant Liposomes, Adv. Funct. Mater., 25 (2015) 3330-3340. (Co-first author)

[17] B. Herranz‐Blanco, D. Liu, E. Mäkilä, M.A. Shahbazi, E. Ginestar, H. Zhang, V. Aseyev, V. Balasubramanian, J. Salonen, J. Hirvonen, On‐Chip Self‐Assembly of a Smart Hybrid Nanocomposite for Antitumoral Applications, Adv. Funct. Mater., 25 (2015) 1488-1497.

2014 (4)

[16] H. Zhang, M.-A. Shahbazi, P.V. Almeida, H.A. Santos, Mucus as a barrier for biopharmaceuticals and drug delivery systems,  Mucosal Delivery of Biopharmaceuticals, Springer US2014, pp. 59-97.

[15] H. Zhang, D. Liu, M.A. Shahbazi, E. Mäkilä, B. Herranz‐Blanco, J. Salonen, J. Hirvonen, H.A. Santos, Fabrication of a Multifunctional Nano‐in‐micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix, Adv. Mater., 26 (2014) 4497-4503.

[14] N. Shrestha, M.-A. Shahbazi, F. Araújo, H. Zhang, E.M. Mäkilä, J. Kauppila, B. Sarmento, J.J. Salonen, J.T. Hirvonen, H.A. Santos, Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers, Biomaterials, 35 (2014) 7172-7179.

[13] D. Liu, H. Zhang, B. Herranz‐Blanco, E. Mäkilä, V.P. Lehto, J. Salonen, J. Hirvonen, H.A. Santos, Microfluidic Assembly of Monodisperse Multistage pH‐Responsive Polymer/Porous Silicon Composites for Precisely Controlled Multi‐Drug Delivery, Small, 10 (2014) 2029-2038.

2013 (4)

[12] H. Zhang, M.-A. Shahbazi, E.M. Mäkilä, T.H. da Silva, R.L. Reis, J.J. Salonen, J.T. Hirvonen, H.A. Santos, Diatom silica microparticles for sustained release and permeation enhancement following oral delivery of prednisone and mesalamine, Biomaterials, 34 (2013) 9210-9219.

[11] T. Suominen, P. Uutela, R.A. Ketola, J. Bergquist, L. Hillered, M. Finel, H. Zhang, A. Laakso, R. Kostiainen, Determination of serotonin and dopamine metabolites in human brain microdialysis and cerebrospinal fluid samples by UPLC-MS/MS: discovery of intact glucuronide and sulfate conjugates, Plos One, 8 (2013) e68007.

[10] M.-A. Shahbazi, M. Hamidi, E.M. Mäkilä, H. Zhang, P.V. Almeida, M. Kaasalainen, J.J. Salonen, J.T. Hirvonen, H.A. Santos, The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility, Biomaterials, 34 (2013) 7776-7789.

[9] D. Liu, E. Mäkilä, H. Zhang, B. Herranz, M. Kaasalainen, P. Kinnari, J. Salonen, J. Hirvonen, H.A. Santos, Nanostructured Porous Silicon‐Solid Lipid Nanocomposite: Towards Enhanced Cytocompatibility and Stability, Reduced Cellular Association, and Prolonged Drug Release, Adv. Funct. Mater., 23 (2013) 1893-1902.

2012 (4)

[8] L. Zhu, G. Ge, H. Zhang, H. Liu, G. He, S. Liang, Y. Zhang, Z. Fang, P. Dong, M. Finel, Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms, Drug Metab. Disposition, 40 (2012) 529-538.

[7] H. Zhang, A. Soikkeli, A. Tolonen, T. Rousu, J. Hirvonen, M. Finel, Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases, Toxicol. In Vitro, 26 (2012) 1286-1293.

[6] H. Zhang, A.-S. Patana, P.I. Mackenzie, S. Ikushiro, A. Goldman, M. Finel, Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics, Drug Metab. Disposition, 40 (2012) 1935-1944.

[5] H. Zhang, UGTs and glucuronidation analyses in Caco-2 cells, human microsomes and recombinant enzymes, (2012).

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[4] H. Zhang, A. Tolonen, T. Rousu, J. Hirvonen, M. Finel, Effects of cell differentiation and assay conditions on the UDP-glucuronosyltransferases activity in Caco-2 cells, Drug Metab. Disposition, (2010) dmd. 110.036582.

[3] J. Telenius, A.E. Wallin, M. Straka, H. Zhang, E.J. Mancini, R. Tuma, RNA packaging motor: From structure to quantum mechanical modelling and sequential-stochastic mechanism, Computational and Mathematical Methods in Medicine, 9 (2008) 351-369.

[2] S. Siissalo, H. Zhang, E. Stilgenbauer, A.M. Kaukonen, J. Hirvonen, M. Finel, The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells, Drug Metab. Disposition, 36 (2008) 2331-2336.

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