Research group: Precision Nanomedicine and Diagnostic Group

Nanobiotechnology is a novel discipline that indicate the merger of biological and nanotechnology. It is a multidisciplinary subject, which interplay between physics, materials science, synthetic organic chemistry, engineering and biology.

To efficiently diagnostic and treat diseases, the understanding of detail mechanism of disease occur would be critical. The qualitative and quantitative analysis at the molecular scope in real time is highly demanded but very challenging to achieve. Nanobiotechnology is to solve the fascinating problems offered by biology through designing and synthesizing of specific nanomaterials and utilize specific techniques.

DNA nanotechnology is one important example of nanobiotechnology. As the central genetic molecule in biological systems, DNA possesses many exceptional properties, including its biological function, biocompatibility, molecular recognition ability, and nanoscale controllability. These unique attributes enabled the creation of functional DNA nanostructures, which act as natural bridge between nanotechnology and biotechnology, leading to far-ranging real-world applications.

Microfluidic technology is revolutionary for high throughput diagnostics and other biological applications. We are collaborating with Prof. David. A Weitz in Harvard University (http://weitzlab.seas.harvard.edu) and we will develop and utilize microfluidic techniques for Single Cell RNA-Sequencing, Single-cell analysis and screening; on-chip screening, diagnostic; and microfluidic templated nano/micro-particles fabrication and encapsulation.

Contact: hongbo.zhang@abo.fi

Publications

2020 (20) 

[103] Jie Shen, Ming Ma, Hongbo Zhang, Huizhu Yu, Fengfeng Xue, Nanjing Hao, Hangrong Chen. "Microfluidics-Assisted Surface Tri-Functionalization of Zeolitic Imidazolate Framework Nanocarrier for Targeted and Controllable Multitherapies of Tumor".  ACS Appl. Mater. Interfaces 2020. (accepted)

[102] Ruoyu Cheng, Flavia Fontana, Junyuan Xiao, Zehua Liu, Patrícia Figueiredo, Mohammad-Ali Shahbazi, Shiqi Wang, Jing Jin, Giulia Torrieri, Jouni T. Hirvonen, Hongbo Zhang, Tongtong Chen, Wenguo Cui*, Yong Lu*, Hélder A. Santos*, “Recombination Monophosphoryl Lipid A Derived Vacosome for the Development of Preventive Cancer Vaccines”, ACS Appl. Mater. Interfaces 2020. (accepted)

[101] Ye Liang, Yonghua Wang, Liping Wang, Zhijuan Liang, Dan Li, Xiaoyu Xu, Yuanbin Chen, Xuecheng Yang*, Hongbo Zhang*, HaitaoNiu*. "Self-crosslinkable Chitosan-Hyaluronic Acid Dialdehyde Nanoparticles for CD44-targeted siRNA Delivery to Treat Bladder Cancer". Bioactive Materials, 2020, Accepted.  

[100] Minghua Yao, Xiaojing Shi, Changjing Zuo, Ming Ma,* Lu Zhang, Hongbo Zhang, Xin Li, Guo-Yuan Yang, Yaohui Tang,* Rong Wu.* "Engineering of SPECT/Photoacoustic Imaging/Antioxidative-Stress Triple-Function Nanoprobe for Advanced Mesenchymal Stem Cell Therapy of Cerebral Ischemia".  ACS Appl. Mater. Interfaces 2020, Accepted.

[99] Guicai Li, Qi Han, Liling Zhang, Panjian Lu, Yuezhou Zhang, Shiyu Chen, Ping Zhang, Luzhong Zhang, Wenguo Cui, Hongkui Wang, Hongbo Zhang*. "Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration". Research 2020, Accepted.

[98] Jiaqi Yan, Chang Liu, Qiwei Wu, Junnian Zhou, Xiaoyu Xu, Lirong Zhang, Dongqing Wang, Fan Yang, Hongbo Zhang*. "Mineralization of pH sensitive Doxorubicin Prodrug in ZIF-8 to Enable the Target Delivery to Solid Tumors" Analytical Chemistry, 2020 Accepted.

[97] Amit Kumar Rajora,* Divyashree RavishankarHongbo Zhang, Jessica M. Rosenholm. "Recent advances and impact of nanoformulations of chemo- and antiangiogenesis for combination cancer therapy". Pharmaceutics 2020, 12(6), 592; https://doi.org/10.3390/pharmaceutics12060592

[96] Emilia Palo, Hongbo Zhang, Mika Lastusaari, Mikko Oskari Salomäki.  "Nanometer-Thick Ion-Selective Polyelectrolyte Multilayer Coatings to Inhibit the Disintegration of Inorganic Upconverting Nanoparticles" ​ACS Appl. Nano Mater. 2020​, Accepted.

[95] Yang Ye, Jian He, Yue Qiao, Yuchen Qi, Hongbo Zhang, Hélder A. Santos, Danni Zhong, Wanlin Li, Shiyuan Hua, Wei Wang, Andrzej Grzybowski, Ke Yao*, Min Zhou*, “Mild Temperature Photothermal Assisted Anti-Bacterial and Anti-Inflammatory Nanosystem for Synergistic Treatment of Post-Cataract Surgery Endophthalmitis”, Theranostics 2020, 10(19), 8541-8557.

[94] Chang Liu; Xiaoyu Xu; Junnian Zhou; Jiaqi Yan; Dongqing Wang; Hongbo Zhang*. "Redox-responsive Tumor Targeted Dual-drug Loaded Biocompatible Metal-organic Frameworks Nanoparticles for Enhancing Anticancer Effects", BMC Mater. 2020 (Accepted).

[93] Xiaoyu Xu; Oliver Koivisto; Chang Liu; Daqi Wang; Junnian Zhou; Mitro Miihkinen; Guillaume Jacquemet; Jessica Rosenholm*; Yilai Shu*; Hongbo Zhang*.  "Effective delivery of the CRISPR/Cas9 system enabled by functionalized mesoporous silica nanoparticles for GFP-tagged paxillin knock-in", Adv Ther, 2020, https://doi.org/10.1002/adtp.202000072

[92] Kawthar Mohamed, Eduardo Rodríguez-Román, Farzaneh Rahmani, Hongbo Zhang, Mariya Ivanovska, Sara A. Makka, Musa Joya, Rangarirai Makuku, Md Shahidul Islam, Nesrine Radwan, Laila Rahmah, Rayan Goda, Sunny O. Abarikwu, Mujtaba Shaw, Samaneh Zoghi, Sevan Irtsyan , Irene Ling, Orsolya Cseprekal, Attig-Bahar Faten, Esra Hazar Sayar, Chagajeg Soloukey, Giulia Grancini, Nima Rezaei. International Efforts to Save Healthcare Personnel during COVID-19. Acta Biomedica Atenei Parmensis, 2020, 3/20 (September) , COVID-19 UPDATE section. 

[91] Yunzhan Li, Zehua Liu, Li Li, Wenhua Lian, Yaohui He, Elbadry Khalil, Ermei Mäkilä, Wenzhong Zhang, Giulia Torrieri, Xueyan Liu, Jingyi Su, Yuanming Xiu, Flavia Fontana, Jarno Salonen, Jouni Hirvonen, Wen Liu, Hongbo Zhang*, Hélder A. Santos*, Xianming Deng*, “Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses Under Diseased Condition”, Adv. Sci. 2020. (https://doi.org/10.1002/advs.202001129)

[90] Kawthar Mohamed, Eduardo Rodríguez-Román, Farzaneh Rahmani, Hongbo Zhang, Mariya Ivanovska, Sara A. Makka, Musa Joya, Rangarirai Makuku, Md Shahidul Islam, Nesrine Radwan, Laila Rahmah, Rayan Goda, Sunny O. Abarikwu, Mujtaba Shaw, Samaneh Zoghi, Sevan Irtsyan, Irene Ling, Orsolya Cseprekal, Attig-Bahar Faten, Esra Hazar, Chagajeg Soloukey Tbalvandany, Giulia Grancini, Nima Rezaei, "Borderless collaboration is needed for COVID-19; a disease that knows no borders", Infection Control & Hospital Epidemiology, 2020, 1-7

[89] Liucheng Zhang, Yi Xiang, Hongbo Zhang, Liying Cheng, Xiyuan Mao, Ning An, Lu Zhang, Jinxiong Zhou, Lianfu Deng, Yuguang Zhang*, Xiaoming Sun*, Hélder A. Santos*, Wenguo Cui*, “Biomimetic 3D-Self-Forming Approach For Microvascular Scaffolds”, Adv. Sci. 2020, 7, 1903553 (Co-first author)

[88] Jiaqi Yan, Xiaoyu Xu, Junnian Zhou, Chang Liu, Lirong Zhang, Dongqing Wang, Fan Yang, Hongbo Zhang*, ” Fabrication of a pH/redox-triggered mesoporous silica-based nanoparticle with microfluidics for anti-cancer drugs doxorubicin and paclitaxel co-delivery”, ACS Applied Bio Materials, 2020, 3, 2, 1216–1225 (corresponding author).

[87] Jian He, Yue Qiao, Hongbo Zhang, Jun Zhao,Wanli Li, Tingting Xie, Danni Zhong, Qiaolin Wei, Shiyuan Hua, Yinhui Yu, Ke Yao, Hélder A. Santos*, Min Zhou*, “Gold-Silver Nanoshells Promote Wound Healing from Drug-Resistant Bacteria Infection and Enable Monitoring via Surface-Enhanced Raman Scattering Imaging”, Biomaterials 2020, 234, 119763. (Co-first author)

[86] Guohong Cao, Yangyang Li, Yucheng Qi, Yue Qiao, Jian He, Hongbo Zhang*, Wenguo Cui*, Min Zhou*, "NIR-responsible and optically monitored nanoparticles release from electrospinning fibrous matrices", Mater. Today. Adv. 2020, 6, 100044

 (Corresponding author).

[85] Ruoyu Cheng, Lili Liu, Yi Xiang, Yong Lu, Lianfu Deng, Hongbo Zhang*, Hélder A. Santos*, Wenguo Cui*, “Advanced Liposome-Loaded Scaffolds for Therapeutic and Tissue Engineering Applications”, Biomaterials 2020, 232, 119706. (Corresponding author)

[84] Yusen Qiao, Xingzhi Liu, Xichao Zhou, Hongbo Zhang, Wen Zhang, Wei Xiao, Guoqing Pan, Wenguo Cui*, Hélder A. Santos*, Qin Shi*, “Gelatin Templated Polypeptide Co-crosslinked Hydrogel for Bone Regeneration”, Adv. Healthcare Mater. 2020, 9(1), 1901239. (Co-first author)

2019 (18)

[83Guicai Li, Xueying Zhao, Luzhong Zhang, Jian Yang, Wenguo Cui, Yumin Yang, Hongbo Zhang*. “Anisotropic ridge/groove microstructure for regulating morphology and biological function of Schwann cells”, Applied Materials Today, 2019, 18, 100468 (Corresponding author)

[82] Yimin Wang, Di Wu, Guohua Wu, Jianguo Wu, Siming Lu, James Lo, Yong He, Chao Zhao, Xin Zhao, Hongbo Zhang, ShuQi Wang. "Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy". Theranostics 2019, 10 (1), 300

[81] Yangyang Li, Yuchen Qi, Hongbo Zhang, Zhiming Xia, Tingting Xie, Wanlin Li, Danni Zhong, Huanle Zhu, Min Zhou, "Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostics", Biomaterials, 2019, 119538 (Co-first author)

[80] Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang*, Hélder A. Santos*, Hongxing Shen*, “Gene-Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus”, Adv. Sci. 2020, 7(1), 1902099.

[79Jincheng Tang, Yong Gu, Hongbo Zhang, Liang Wu, Yun Xu, Jiannan Mao, Tianwen Xin, Tingjun Ye, Lianfu Deng, Wenguo Cui*, Hélder A. Santos*, Liang Chen*, “Outer-Inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis”, Nanoscale 2019, 11, 15794–15803. (Co-first author)

[78] Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu, Lu Gan*, Hélder A. Santos*, Xiangliang Yang*, “Tumor Exosome-Based Nanoparticles are Efficient Drug Carriers for Chemotherapy”, Nature Commun. 2019, 10(1), 3838. (Co-first author)

[77] Diosangeles Soto Veliz*, Hongbo Zhang, Martti Toivakka. "Stacking up: a new approach for cell culture studies".  Biomaterials Science, 2019. 7 (8), 3249-3257

[76]  Ranjith Kumar Kankala, Hongbo Zhang, Chen-Guang Liu, Kiran Reddy Kanubaddi, Chia-Hung Lee, Shi-Bin Wang, Wenguo Cui*, Hélder A. Santos*, KaiLi Lin*, Ai-Zheng Chen*, “Metal Species-Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs”, Adv. Funct. Mater. 2019, 29(43), 1902652. (Review) (Co-first author)

[75]  Yue Qiao, Yuan Ping, Hongbo Zhang, Fengyong Liu, Bo Zhou, Yinhui Yu, Tingting Xie, Wanli Li, Danni Zhong, Yuezhou Zhang, Ke Yao, Hélder A. Santos*, Min Zhou*, “Laser Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Wound Healing for Infected Chronic Nonhealing Wounds”, ACS Appl. Mater. Interfaces 2019, 11(4), 3809–3822. (Co-first author)

[74]  Hongbo Zhang, Wenguo Cui, Xiangmeng Qu, Huayin Wu, Liangliang Qu, Xu Zhang, Ermei Mäkilä, Jarno Salonen, Yue-Qi Zhu*, Zhou Yang, Dong Chen, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Photothermal Responsive Nanosized Hybrid Polymersome as Versatile Therapeutics Co-Delivery Nanovehicle for Effective Tumor Suppression”, Proc. Natl. Acad. Sci. U.S.A. 2019, 116(16) 7744–7749.

[73] Xiaodong Ma,  Ezgi Ozliseli,  Yuezhou Zhang,  Guoqing Pan,  Dongqing WangHongbo Zhang*. ​"Fabrication of Redox- Responsive Doxorubicin and Paclitaxel Prodrug Nanoparticles with Microfluidics for Selective Cancer Therapy". Biomaterials Science, 2019. 7 (2), 634-644 (Corresponding author)

[72] Yufei Yan, Hao Chen, Hongbo Zhang, Changjun Guo, Kai Yang, Kaizhe Chen, Ruoyu Cheng, Niandong Qian, Niklas Sandler, Yu Shrike Zhang, Haokai Shen, Jin Qi, Wenguo Cui, Lianfu Deng. Vascularized 3D printed scaffolds for promoting bone regeneration. Biomaterials, 2018, 190, 97-110 (Co-first author)

[71]  Zehua Liu, Yunzhan Li, Wei Li*, Wenhua Lian, Marianna Kemell, Sami Hietala, Patrícia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang*, Xianming Deng*, Hélder A. Santos*, “Close-loop Dynamic Nanohybrids on Collagen-Ark with In-situ Gelling Transformation Capability for Bio-mimetically Stage Specific Diabetic Wound Healing”, Mater. Horiz. 2019, 6, 385–393. (Corresponding author)

[70]  Yufei Yan, Tao Sun, Hongbo Zhang, Xiuling Ji, Yulong Sun, Xin Zhao, Lianfu Deng, Jin Qi*, Wenguo Cui*, Hélder A. Santos*, Hongyu Zhang*, “Euryale Ferox Seed-inspired Super-lubricated Nanoparticles for Treatment of Osteoarthritis”, Adv. Funct. Mater. 2019, 29(4), 1807559. (Co-first author)

[69] Yuezhou Zhang, Dongfei Liu, Hongbo Zhang*, Hélder A. Santos,* "Chapter 7: Microfluidic Mixing and Devices for Preparing Nanoparticulate Drug Delivery Systems". In: Microfluidics for pharmaceutical applications: from nano/micro systems fabrication to controlled drug delivery, Santos H. A., Liu D., and Zhang H. (Eds.), Elsevier B.V. 2019, 155–177. (Corresponding author)

[68]  Shengcai Qi, Pengfei Zhang, Ming Ma*, Minghua Yao, Jinjin Wu, Ermei Mäkilä, Jarno Salonen, Heikki Ruskoaho, Yuanzhi Xu, Hélder A. Santos*, Hongbo Zhang*, “Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells”, Small 2019, 15(1), 1804332. (Corresponding author)

[67] Xiyuan Mao, Ruoyu Cheng, Hongbo Zhang, Jinhong Bae, Liying Cheng, Lu Zhang, Lianfu Deng, Wenguo Cui*, Yuguang Zhang*, Hélder A. Santos*, Xiaoming Sun*, “Correction to "Self-Healing and Injectable Hydrogel for Matching Skin Flap Regeneration"”, Adv. Sci. 2019, 6(13), 1901124. (Co-first author)

[66] Yueqi Zhu, Hongbo Zhang, Yiran Zhang, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng*, Minghua Li*, Hélder A. Santos*, Wenguo Cui*, “Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases”, Adv. Mater. 2019, 31(8), 1805452. (Co-first author)

2018 (17) 

[65] Xiaobin Guo, Yu Liu, Jiaxiang Bai, Binqing Yu, Menglei XuHouyi Sun, Jining Shen, Jiayi Lin, Hongbo ZhangDongqing WangDechun Geng, Guoqing Pan, "Efficient Inhibition of Wear‐Debris‐Induced Osteolysis by Surface Biomimetic Engineering of Titanium Implant with a Mussel‐Derived Integrin‐Targeting Peptide", Advanced Biosystems, 2018, 3(2),1800253

[64] Minghua Yao, Ming Ma*, Hongbo Zhang, Gang Wan, Yuezhou Zhang, Hangrong Chen*, Rong Wu*, “Theranostic Role of Cobalt Protoporphyrin Nano-Formulation for Photoacoustic Imaging Guided Stem Cell Implantation”. Adv. Funct. Mater. 2018. 28(47), 1804497

[63]  Wei Li, Yunzhan Li, Zehua Liu, Nattha Kerdsakundee, Ming Zhang, Feng Zhang, Xueyan Liu, Tomás Bauleth-Ramos, Wenhua Lian, Ermei Mäkilä, Marianna Kemell, Yaping Ding, Bruno Sarmento, Ruedeekorn Wiwattanapatapee, Jarno Salonen, Hongbo Zhang, Jouni T. Hirvonen, Dongfei Liu*, Xianming Deng*, Hélder A. Santos*, “Hierarchical Structured and Programmed Vehicles Deliver Drugs Locally to Inflamed Sites of Intestine”, Biomaterials 2018, 185, 322-332.

[62] Xingzhi Liu, Hongbo Zhang, Ruoyu Cheng, Yanzheng Gu, Yin Yin, Zhiyong Sun, Guoqing Pan, Zhongbin Deng, Huilin Yang, Lianfu Deng, Wenguo Cui*,  Hélder A Santos*, Qin Shi*, “An immunological Electrospun Scaffold for Tumor Imprison Killing and Healthy Tissue Regeneration”, Mater. Horiz. 2018, 5, 1082-1091. (Co-first author)

[61] Xiaoming Sun, Hongbo Zhang, Jinlin He, Ruoyu Cheng, Youwen Cao, Kunming Che, Liying Cheng, Lu Zhang, Guoqing Pan, Peihong Ni, Lianfu Deng, Yuguang Zhang*, Hélder A. Santos*, Wenguo Cui*, “Adjustable hardness of hydrogel for promoting vascularization and maintaining stemness of stem cells in skin flap regeneration”, Appl. Mater. Today 2018, 13, 54-63. (Co-first author)

[60]  Guanggai Xia, Hongbo Zhang, Ruoyu Cheng, Hongcheng Wang, Ziliang Song, Lianfu Deng, Xinyu Huang*, Hélder A. Santos*, Wenguo Cui*, “Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence”, Adv. Healthcare Mater. 2018, 7(18), 1800593. (Co-first author)

[59]  Dongfei Liu*, Katriina Lipponen, Peng Quan, Xiaocao Wan, Hongbo Zhang, Ermei M. Mäkilä, Jarno J. Salonen, Risto Kostiainen, Jouni J. Hirvonen, Tapio Kotiaho, Hélder A. Santos*, “Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions”, ACS Biomater. Sci. Eng. 2018, 4(7), 2308–2313.

[58] Book editing: Microfluidics for Pharmaceutical Applications, 560 pages, ISBN 9780128126592 .  

[57] Jianfeng Ji, Fei Ma, Hongbo Zhang, Fengyong Liu, Jian He, Wanlin Li, Tingting Xie, Danni Zhong, Tingting Zhang, Mei Tian*, Hong Zhang*, Hélder A. Santos*, Min Zhou*, “Light-Activatable Assembled Nanoparticles to Improve Tumor-Penetration and Eradicate Metastasis in Triple Negative Breast Cancer”, Adv. Funct. Mater. 2018, 28(33), 1801738. (Co-first author)

[56] Feng Zhang, Li Kong, Dongfei Liu, Wei Li, Ermei Mäkilä, Alexandra Correia, Rici Lindgren, Jarno Salonen, Jouni T. Hirvonen, Hongbo Zhang, Alexander Kros, Hélder A. Santos*, “Sequential Antifouling Surface for Efficient Modulation of the Nanoparticle-Cell Interactions in Protein-Rich Environment”, Adv. Ther. 2018, 1(1), 1800013.

[55] Ruibo Zhong, Qian Tang, Shaopeng Wang, Hongbo Zhang, Feng Zhang, Mingshu Xiao, Tiantian Man, Xiangmeng Qu, Li Li, Weijia Zhang, Hao Pei.* “Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors”. Advanced Materials 2018. 30(12), 1706887.

[54] Vimalkumar Balasubramanian, Andrea Poillucci, Alexandra Correia, Hongbo Zhang, Christian Celia,* Hélder A. Santos*, “Cell Membranes based Nanoreactor to Mimic the Bio-Compartmentalization Strategy of a Cell”, ACS Biomater. Sci. Eng. 2018, 4(4), 1471–1478.

[53] Hongbo Zhang, Yueqi Zhu, Liangliang Qu, Huayin Wu, Haixin Kong, Zhou Yang, Dong Chen, Ermei Makila, Jarno J. Salonen, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates”, Nano Lett. 2018, 18(2), 1448–1453.

[52] Yuezhou Zhang, Jing Tu, Dongqing Wang, Haitao Zhu, Sajal Kumar Maity, Xiangmeng Qu, Bram Bogaert, Hao Pei, Hongbo Zhang*. Programmable and Multifunctional DNA-Based Materials for Biomedical Applications. Advanced Materials, 2018 30(24), 1703658 (Corresponding author)

[51] Zehua Liu, Yunzhan Li, Wei Li, Chen Xiao, Dongfei Liu, Chao Dong, Ming Zhang, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni T. Hirvonen, Hongbo Zhang*, Dawang Zhou*, Xianming Deng*, Hélder A. Santos*, “Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics”, Adv. Mater. 2018, 30(24), 1703393. (Corresponding author)

[50] Zoran Cenev, Hongbo Zhang*, Veikko Sariola, Antti Rahikkala, Dongfei Liu, Hélder A. Santos*, Quan Zhou*, “Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle”, Adv. Mater. Technol. 2018, 3(1), 1700177. (Corresponding author)

[49] Dongfei Liu*, Hongbo Zhang, Flavia Fontana, Jouni T. Hirvonen, Hélder A. Santos*, “Current Developments and Applications of Microfluidic Technology Toward Clinical Translation of Nanomedicines”, Adv. Drug Deliv. Rev. 2018, 128, 54–83. (Invited Review)

​2017 (17)

[48] Xiangmeng Qu, Min Li, Hongbo Zhang, Chenglie Lin, Fei Wang, Mingshu Xiao, Yi Zhou, Jiye Shi, Ali Aldalbahi, Hao Pei, Hong Chen, Li Li. Real-Time Continuous Identification of Greenhouse Plant Pathogens Based on Recyclable Microfluidic Bioassay System. ACS Applied Materials & Interfaces 2017, 9 (37), pp 31568–31575

[47] Hongbo Zhang*, Dongfei Liu, Liang Wang, Zehua Liu, Runrun Wu, Agne Janoniene, Ming Ma, Guoqing Pan, Lina Baranauskiene, Linlin Zhang, Wenguo Cui, Vilma Petrikaite, Daumantas Matulis, Hongxia Zhao, Jianming Pan*, Hélder A. Santos*, “Microfluidic Encapsulation of Prickly Zinc-doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy”, Adv. Healthcare Mater. 2017, 6(11), 1601406.

[46] Tomás Bauleth-Ramos, Mohammad-Ali Shahbazi*, Dongfei Liu, Flavia Fontana, Alexandra Correia, Patrícia Figueiredo, Hongbo Zhang, João Pedro Martins, Jouni T. Hirvonen, Pedro Granja, Bruno Sarmento*, Hélder A. Santos*, “Nutlin-3a and Cytokine co-loaded Spermine-modified Acetalated Dextran Nanoparticles for Cancer Chemo-immunotherapy”, Adv. Funct. Mater. 2017, 27(42), 1703303. 

[45] Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi MH Salo‐Ahen, Ronald Österbacka, John E Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler, Tailored approaches in drug development and diagnostics – from molecular design to biological model systems(Review). Advanced Healthcare Materials, 2017, 6, 1700258

[44] Henni Auvinen, Hongbo Zhang, Nonappa, Alisa Kopilow, Elina H. Niemelä, Sami Nummelin, Alexandra Correia, Hélder A. Santos, Veikko Linko*, Mauri A. Kostiainen*, “Protein Coating of DNA Nanostructures for Enhanced Delivery, Stability and Immunocompatibility”, Adv. Healthcare Mater. 2017, 6(18), 1700692.

[43] Xiangmeng Qu, Fan YangHong ChenJiang LiHongbo ZhangGuo-Jun ZhangLi Li, Lihua Wang, Shiping SongYang Tian, and Hao Pei*. "Bubble-Mediated Ultrasensitive Multiplex Detection of Metal Ions in Three-Dimensional DNA Nanostructure-Encoded Microchannels". ACS Appl. Mater. Interfaces 2017. 9 (19), 16026-16034

[42] Agne Janoniene, Zehua Liu, Lina Baranauskiene, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni Hirvonen, Honbgo Zhang*, Vilma Petrikaite*, Hélder A. Santos*, “A Versatile Carbonic Anhydrase IX Targeting Ligand Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging”, ACS Appl. Mater. Interfaces 2017, 9(16), 13976–13987.

[41] Elisa Ollikainen, Dongfei Liu, Arttu Kallio, Ermei Mäkilä, Hongbo Zhang, Jarno Salonen, Hélder A. Santos, Tiina Sikanen*, “The Impact of Porous Silicon Nanoparticles on Human Cytochrome P450 Metabolism in Human Liver Microsomes In Vitro”, Eur. J. Pharm. Sci. 2017, 104, 124–132.

[40] Hongbo Zhang, Xiangmeng Qu, Hong Chen, Ruihua Ding, Dong Chen, Weixia Zhang, Xu Zhang, Hao Pei, Hélder A. Santos, Mingtan Hai*, David A. Weitz*, “Fabrication of Calcium Phosphate-based Nanocomposites Containing DNA Origami, Gold nanorods and Drugs for Synergistic Anticancer Applications”, Adv. Healthcare Mater. 2017, 6(20), 1700664.

[39] Feng Zhang, Alexandra Correia, Ermei M. Mäkilä, Wei Li, Jarno J. Salonen, Jouni Hirvonen, Hongbo Zhang*, Hélder A. Santos*, “Receptor-Mediated Surface Charge Inversion Platform Based on Porous Silicon Nanoparticles for Efficient Cancer Cell Recognition and Combination Therapy”, ACS Appl. Mater. Interfaces 2017, 9(11), 10034–10046. (Corresponding author)

[38] Xiaoming Sun, Qi Lang, Hongbo Zhang, Liying Cheng, Ying Zhang, Guoqing Pan, Xin Zhao, Huilin Yang, Yuguang Zhang*, Hélder A. Santos*, Wenguo Cui*, “Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid in Vivo Vascularized Skin Flap Regeneration”, Adv. Funct. Mater. 2017, 27(2), 1604617. (Co-first author)

[37] Xiangmeng Qu, Hongbo Zhang, Hong Chen, Ali Aldalbahi, Li Li, Yang Tian, David A Weitz, Hao Pei*, Convection-Driven Pull-Down Assays in Nanoliter Droplets Using Scaffolded Aptamers, Anal. Chem., 2017,6, 3468-3473

[36] Dongfei Liu*, Hongbo Zhang, Salvatore Cito, Jin Fan, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Tiina M. Sikanen, David A. Weitz, Hélder A. Santos*, “Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation”, Nano Lett. 2017, 17(2), 606–614.

[35] Wei Li, Dongfei Liu, Hongbo Zhang, Alexandra Correia, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos, Hélder A. Santos*, “Microfluidic Assembly of a Nano-in-Micro Dual Drug Delivery Platform Composed of Halloysite Nanotubes and a pH-Responsive Polymer for Colon Cancer Therapy”, Acta Biomater. 2017, 48, 238–246.

[34] Bárbara Herranz-Blanco, Eloy Ginestar, Hongbo Zhang, Jouni Hirvonen, Hélder A. Santos*, “Microfluidics Platform for Glass Capillaries and its Application in Droplet and Nanoparticle Fabrication”, Int. J. Pharm. 2017, 516(1-2), 100–105.

[33] Lizhen Chen, Jie Chao, Xiangmeng Qu, Hongbo Zhang, Dan Zhu, Shao Su, Ali Aldalbahi, Lianhui Wang, Hao Pei*, Probing Cellular Molecules with PolyA-Based Engineered Aptamer Nanobeacon, ACS Appl. Mater. Interfaces, 9 (2017) 8014-8020.

[32] Vimalkumar Balasubramanian*, Alexandra Correia, Hongbo Zhang, Flavia Fontana, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos*, “Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-like Functions”, Adv. Mater. 2017, 29(11), 1605375.

2016 (10)

[31] Runrun Wu, Hongbo Zhang, Jianming Pan,* Hengjia Zhu, Yue Ma, Wenguo Cui, Hélder A. Santos*, Guoqing Pan*, “Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing”, Adv. Mater. Interfaces 2016, 3(18), 1600472. (Co-first author)

[30] Ari Ora, Erika Järvihaavisto, Hongbo Zhang, Henni Auvinen, Hélder A. Santos, Mauri A. Kostiainen*, Veikko Linko*, “Cellular Delivery of Enzyme-Loaded DNA Origami”, Chem. Commun. 2016, 52(98), 14161–14164.

[29] Zehua Liu, Vimalkumar Balasubramanian, Chinmay Bhat, Mikko Vahermo, Ermei Mäkilä, Marianna Kemell, Flavia Fontana, Agne Janoniene, Vilma Petrikaite, Jarno Salonen, Jari Yli-Kauhaluoma, Jouni Hirvonen, Hongbo Zhang*, Hélder A. Santos*, “Quercetin-based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells”, Adv. Healthcare Mater. 2017, 6(3), 1601009. (Corresponding author)

[28] Dongfei Liu, Tao Jiang, Weihua Cai, Jian Chen, Hongbo Zhang, Sami Hietala, Hélder A. Santos*, Guoyong Yin*, Jin Fan*, “An In Situ Gelling Drug Delivery System For Improved Recovery After Spinal Cord Injury”, Adv. Healthcare Mater. 2016, 5(12), 1513–1521.

[27] Feng Kong, Hongbo Zhang, Xu Zhang, Dongfei Liu, Dong Chen, Weixia Zhang, Liyuan Zhang, Hélder A. Santos, Mingtan Hai*, “Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications”, Adv. Funct. Mater. 2016, 26(34), 6158–6169. (Co-first author)

[26] Feng Kong, Hongbo Zhang, Xiangmeng Qu, Xu Zhang, Dong Chen, Ermei Mäkilä, Jarno Salonen, Hélder A. Santos, Mingtan Hai*, “Gold Nanorods, DNA Origami and Porous Silicon Nanoparticles Functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy”, Adv. Mater. 2016, 28(46), 10195–10203. (Co-first author)

[25] Hui Guo, Dongmei Liu, Bin Gao, Xiaohui Zhang, Minli You, Hui Ren, Hongbo Zhang, Hélder A. Santos, Feng Xu*, “Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine based on 3D Tumour Models”, Molecules 2016, 21(7), 954.

[24] F. Fontana, M.A. Shahbazi, D. Liu, H. Zhang, E. Mäkilä, J. Salonen, J.T. Hirvonen, H.A. Santos*, Multistaged Nanovaccines Based on Porous Silicon@ Acetalated Dextran@ Cancer Cell Membrane for Cancer Immunotherapy, Adv. Mater., (2016).

[23] Mónica P. A. Ferreira*, Sanjeev Ranjan, Alexandra M. R. Correia, Ermei M. Mäkilä, Sini M. Kinnunen, Hongbo Zhang, Mohammad-Ali Shahbazi, Patrick V. Almeida, Jarno J. Salonen, Heikki J. Ruskoaho, Anu J. Airaksinen, Jouni T. Hirvonen*, Hélder A. Santos*, “In Vitro and In Vivo Assessment of Heart-Homing Porous Silicon Nanoparticles”, Biomaterials 2016, 94, 93–104.

[22] Hao Chen, Peng Jia, Hui Kang, Hongbo Zhang, Yi Liu, Peilang Yang, Yufei Yan, Guilai Zuo, Lei Guo, Min Jiang, Jin Qi, Yuanyuan Liu*, Wenguo Cui*, Hélder A. Santos*, Lianfu Deng.* , “Up-Regulating Hif-1a by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound”, Adv. Healthcare Mater. 2016, 5(8), 907–918.

2015 (5)

[21] R. Vasiliauskas, D. Liu, S. Cito, H. Zhang, M.-A. Shahbazi, T. Sikanen, L. Mazutis, H.A. Santos*, Simple microfluidic approach to fabricate monodisperse hollow microparticles for multidrug delivery, ACS Appl. Mater. Inter., 7 (2015) 14822-14832.

[20] S. Näkki, J. Rytkönen, T. Nissinen, C. Florea, J. Riikonen, P. Ek, H. Zhang, H.A. Santos, A. Närvänen, W. Xu*, Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration, Acta Biomater., 13 (2015) 207-215.

[19] D.F. Liu*, H.B. Zhang, E. Mäkilä, J. Fan, B. Herranz-Blanco, C.F. Wang, R. Rosa, A.J. Ribeiro, J. Salonen, J. Hirvonen, H.A. Santos*, Microfluidic assisted one-step fabrication of porous silicon@acetalated dextran nanocomposites for precisely controlled combination chemotherapy, Biomaterials, 39 (2015) 249-259.

[18] F. Kong#, X. Zhang#, H. Zhang#, X. Qu, D. Chen, M. Servos, E. Mäkilä, J. Salonen, H.A. Santos, M. Hai, Inhibition of Multidrug Resistance of Cancer Cells by Co‐Delivery of DNA Nanostructures and Drugs Using Porous Silicon Nanoparticles@ Giant Liposomes, Adv. Funct. Mater., 25 (2015) 3330-3340. (Co-first author)

[17] B. Herranz‐Blanco, D. Liu, E. Mäkilä, M.A. Shahbazi, E. Ginestar, H. Zhang, V. Aseyev, V. Balasubramanian, J. Salonen, J. Hirvonen, On‐Chip Self‐Assembly of a Smart Hybrid Nanocomposite for Antitumoral Applications, Adv. Funct. Mater., 25 (2015) 1488-1497.

2014 (4)

[16] H. Zhang, M.-A. Shahbazi, P.V. Almeida, H.A. Santos, Mucus as a barrier for biopharmaceuticals and drug delivery systems,  Mucosal Delivery of Biopharmaceuticals, Springer US2014, pp. 59-97.

[15] H. Zhang, D. Liu, M.A. Shahbazi, E. Mäkilä, B. Herranz‐Blanco, J. Salonen, J. Hirvonen, H.A. Santos, Fabrication of a Multifunctional Nano‐in‐micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix, Adv. Mater., 26 (2014) 4497-4503.

[14] N. Shrestha, M.-A. Shahbazi, F. Araújo, H. Zhang, E.M. Mäkilä, J. Kauppila, B. Sarmento, J.J. Salonen, J.T. Hirvonen, H.A. Santos, Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers, Biomaterials, 35 (2014) 7172-7179.

[13] D. Liu, H. Zhang, B. Herranz‐Blanco, E. Mäkilä, V.P. Lehto, J. Salonen, J. Hirvonen, H.A. Santos, Microfluidic Assembly of Monodisperse Multistage pH‐Responsive Polymer/Porous Silicon Composites for Precisely Controlled Multi‐Drug Delivery, Small, 10 (2014) 2029-2038.

2013 (4)

[12] H. Zhang, M.-A. Shahbazi, E.M. Mäkilä, T.H. da Silva, R.L. Reis, J.J. Salonen, J.T. Hirvonen, H.A. Santos, Diatom silica microparticles for sustained release and permeation enhancement following oral delivery of prednisone and mesalamine, Biomaterials, 34 (2013) 9210-9219.

[11] T. Suominen, P. Uutela, R.A. Ketola, J. Bergquist, L. Hillered, M. Finel, H. Zhang, A. Laakso, R. Kostiainen, Determination of serotonin and dopamine metabolites in human brain microdialysis and cerebrospinal fluid samples by UPLC-MS/MS: discovery of intact glucuronide and sulfate conjugates, Plos One, 8 (2013) e68007.

[10] M.-A. Shahbazi, M. Hamidi, E.M. Mäkilä, H. Zhang, P.V. Almeida, M. Kaasalainen, J.J. Salonen, J.T. Hirvonen, H.A. Santos, The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility, Biomaterials, 34 (2013) 7776-7789.

[9] D. Liu, E. Mäkilä, H. Zhang, B. Herranz, M. Kaasalainen, P. Kinnari, J. Salonen, J. Hirvonen, H.A. Santos, Nanostructured Porous Silicon‐Solid Lipid Nanocomposite: Towards Enhanced Cytocompatibility and Stability, Reduced Cellular Association, and Prolonged Drug Release, Adv. Funct. Mater., 23 (2013) 1893-1902.

2012 (4)

[8] L. Zhu, G. Ge, H. Zhang, H. Liu, G. He, S. Liang, Y. Zhang, Z. Fang, P. Dong, M. Finel, Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms, Drug Metab. Disposition, 40 (2012) 529-538.

[7] H. Zhang, A. Soikkeli, A. Tolonen, T. Rousu, J. Hirvonen, M. Finel, Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases, Toxicol. In Vitro, 26 (2012) 1286-1293.

[6] H. Zhang, A.-S. Patana, P.I. Mackenzie, S. Ikushiro, A. Goldman, M. Finel, Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics, Drug Metab. Disposition, 40 (2012) 1935-1944.

[5] H. Zhang, UGTs and glucuronidation analyses in Caco-2 cells, human microsomes and recombinant enzymes, (2012).

Before 2012 (4)

[4] H. Zhang, A. Tolonen, T. Rousu, J. Hirvonen, M. Finel, Effects of cell differentiation and assay conditions on the UDP-glucuronosyltransferases activity in Caco-2 cells, Drug Metab. Disposition, (2010) dmd. 110.036582.

[3] J. Telenius, A.E. Wallin, M. Straka, H. Zhang, E.J. Mancini, R. Tuma, RNA packaging motor: From structure to quantum mechanical modelling and sequential-stochastic mechanism, Computational and Mathematical Methods in Medicine, 9 (2008) 351-369.

[2] S. Siissalo, H. Zhang, E. Stilgenbauer, A.M. Kaukonen, J. Hirvonen, M. Finel, The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells, Drug Metab. Disposition, 36 (2008) 2331-2336.

[1] M. Dong, B.R. LU, H.B. ZHANG, J.K. CHEN, B. Li, Role of sexual reproduction in the spread of an invasive clonal plant Solidago canadensis revealed using intersimple sequence repeat markers, Plant Species Biol., 21 (2006) 13-18.

 

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