Pharmaceutical Sciences Laboratory

The Translational ADME and Pharmacodynamics group aims to identify key factors affecting drug response in humans. In particular, our research focuses on drug-metabolizing enzymes and drug transporters. We combine laboratory experiments, computer simulations (physiologically-based pharmacokintetic (PBPK) modelling), and data science, and collaborate with clinical researchers to understand, predict and, in the end, improve therapeutic drug response and drug safety.

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We are especially interested is improving drug safety during pregnancy, and in developing methods that can be used in early drug development to screen for potential teratogenic effects.