Maren Katherina Preis, Dr. rer. nat.

PharmaFabLab
Assisting group leader
Pharmacist
Certified Specialist for Pharmaceutical Technology
Project researcher (funded by the Academy of Finland)

Pharmaceutical Sciences Laboratory
Faculty of Science and Engineering
Åbo Akademi University
BioCity (3rd floor, Room 3071)
Tykistökatu 6A
20520 Turku, Finland
Tel + 358 2 2154268
Email: mpreis@abo.fi
 

Research areas

Innovative Drug Delivery & Dosage Form Development
  • Age appropriate / Paediatric dosage forms
  • Oromucosal film preparations
  • Orodispersible and buccal films
  • Characterization of oral dosage forms / Development of new test methods
  • Taste masking strategies and in-vitro assessment
  • Printing technologies for the fabrication of drug delivery systems (2D & 3D printing)

CV

2004 -2009

2009

2009-2010

2010-2014

2010-2013

2012-2015

2014-2015

2015-

Pharmacy studies - Heinrich-Heine University, Düsseldorf, Germany

Graduate R&D Intern - Pharmaceutical & Medical Chemistry, Heinrich-Heine University, Düsseldorf, Germany

Pharmacy trainee to obtain German Pharmacist License, Marien Apotheke, Neuss, Germany

PhD Candidate - Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, Düsseldorf, Germany

Certification as Specialist for Pharmaceutical Technology - Chamber of Pharmacists, Germany

Formulation scientist - Sapiotec GmbH, Würzburg, Germany

Postdoc - Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, Düsseldorf, Germany

Postdoc - Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku, Finland

Publications

Original publications

 

  1. Palo M, Kogermann K, Laidmäe I, Meos A, Preis M, Heinämäki J, et al. Development of Oromucosal Dosage Forms by Combining Electrospinning and Inkjet Printing. Molecular Pharmaceutics. 2017.​

  2. Preis M, Breitkreutz J. Pediatric Drug Development and Dosage Form Design. AAPS PharmSciTech. 2017;18(2):239-40.

  3. Preis M and Öblom H. 3D-Printed Drugs for Children?Are We Ready Yet? AAPS PharmSciTech 2017;18(2):303-8.

  4. H.Wickström, J.O. Nyman, M.Indola, H.Sundelin, L.Kronberg, M.Preis, J.Rantanen, N. Sandler, Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations. AAPS PharmSciTech, 2016

  5. Vakili, H., Nyman, J.O., Genina, N., Preis, M., Sandler, N., Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride. International Journal of Pharmaceutics, 2016, 551, 606-61

  6. Preis, M., Grother, L., Axe, P., Breitkreutz, J., In vitro and in vivo evaluation of taste-masked Cetirizine hydrochloride formulated in oral lyophilisates. International Journal of Pharmaceutics, 2015, 491, 8-16

  7. Preis, M., Gronkowsky, D., Grytzan, D., Breitkreutz, J., Comparative study on novel test systems to determine disintegration time of orodispersible films. Journal of Pharmacy and Pharmacology 2014, 66, 1102-1111

  8. Preis, M., Häusler, O., Breitkreutz, J., Application of electronic tongues in preformulation studies to evaluate taste-masking capacities of maltodextrins. Die Pharmazeutische Industrie: pharmind 2014, 76, 957-962

  9. Preis, M., Woertz, C., Schneider, K., Kukawka, J., Broscheit, J., Roewer, N., Breitkreutz, J., Design and evaluation of bilayered oromucosal film preparations for local administration of lidocaine hydrochloride. European Journal of Pharmaceutics and Biopharmaceutics 2014, 86, 552-561

  10. Guhmann M., Preis M., Gerber F., Pöllinger N., Breitkreutz J., Weitschies W., Design, development and in vitro evaluation of a diclofenac taste masked orally disintegrating tablet formulation. Drug Development and Industrial Pharmacy 2015, 41, 540-551

  11. Preis, M., Knop, K., Breitkreutz, J., Mechanical strength test for orodispersible and buccal films. International Journal of Pharmaceutics 2014, 461, 22-29

  12. Preis, M., Eckert, C., Haeusler, O., Breitkreutz, J., A comparative study on solubilizing and taste-masking capacities of hydroxypropyl-ß-cyclodextrin and maltodextrins with high amylose content. Sensors & Actuators B: Chemical 2014, 193, 442-450

  13. Pein, M., Eckert, C., Preis, M., Breitkreutz, J., New protocol for αAstree electronic tongue enabling full performance qualification according to ICH Q2. Journal of Pharmaceutical and Biomedical Analysis 2013, 83, 157-163

  14. Preis, M., Pein, M. and Breitkreutz J., Development of a taste-masked orodispersible film containing dimenhydrinate. Pharmaceutics 2012, 4, 551-562

  15. Guhmann, M., Preis, M., Gerber, F., Pöllinger, N., Breitkreutz, J., Weitschies, W., Development of oral taste masked diclofenac formulations using a taste sensing system. International Journal of Pharmaceutics 2012, 438, 81-90

 

Review articles

 

  1. N. Sandler & M. Preis. Printed Drug-Delivery Systems for Improved Patient Treatment. Trends in Pharmacological Sciences 2016. (In press)

  2. Krampe, R., Visser, J.C., Frijlink, H.W., Breitkreutz, J., Woerdenbarg, H.J., Preis, M. Oromucosal film preparations: points to consider for patient-centricity and manufacturing processes. Expert Opinion on Drug Delivery. 2015, in press, DOI: 10.1517/17425247.2016.1118048

  3. Preis, M., Orally disintegration films and mini-tablets – innovative dosage form of choice for pediatric use. AAPS PharmSciTech, 2015, 16, 234-241

  4. Preis, M., Breitkreutz, J., Sandler, N., Perspective: Concepts of printing technologies for oral film formulations. International Journal of Pharmaceutics, 2015, in press 10.1016/j.ijpharm.2015.02.032

  5. Preis, M., Woertz, C, Kleinebudde, P., Breitkreutz, J., Oromucosal film preparations: classification and characterization methods. Expert Opinion on drug delivery 2013, 10, 1303-1317

  6. Woertz, C., Preis, M., Breitkreutz, J., Kleinebudde, P., Assessment of test methods evaluating mucoadhesive polymers and dosage forms: An overview. European Journal of Pharmaceutics and Biopharmaceutics 2013, 85, 843 – 853

  7. Pein, M., Preis, M., Eckert, C., Kiene, F., Taste-masking assessment of solid oral dosage forms - a critical review. International Journal of Pharmaceutics 2014, 465, 239-254

 

Non-refereed scientific articles

 

Expert Journals:

 

  1. Beilke, J. Preis, M. Zerfallsprüfung von Schmelzfilmen – Die Entwicklung einer neuen industrietauglichen Testapparatur. TechnoPharm 2014, 4, 334-337. [Disintegration test for orodispersible films – development of a new test apparatus suitable for industry]

  2. Preis, M. and Sandler, N. Personalizing dosage forms by means of printing technologies – A perspective for tailored therapies in the hospitals of tomorrow. Hospital Pharmacy Europe. 2016, in press

  3. Preis, M. Arzneimittel aus dem Drucker – innovative Darreichungsformen in 2D und 3D. TechnoPharm 2016, 6(4) 198-203 [Medicine out of the printer – innovative dosage forms in 2D and 3D]

 

Oral presentations

 

  1. Öblom, H., Pollmann, I., Desai, D., Özliseli, E., Rosenholm, J., Preis, M. Enabling flexible dosing in orodispersible formulations by means of solvent casting and thermal inkjet printing. PSSRC Meeting, Copenhagen 2016

  2. Wickström, H., A. Broos, A., Nyman, J.O., Kortesmäki, E., Eklund, P., de Beer, T., Preis, M., Sandler, N. Quality control of printed doses of levothyroxine and carve, dilol using a handheld colorimeter. PSSRC Meeting, Copenhagen 2016

  3. Speer, I., Hahn, B., Preis, M., Breitkreutz, J. Characterization of ODFs containing drug-loaded matrix particles intending a prolonged theophylline release. PSSRC Meeting, Copenhagen 2016

  4. Speer, I., Preis, M., Breitkreutz, J. Prolonged release properties for orodispersible films combining solvent casting and melt extrusion. World Meeting on Pharmaceutics and Biopharmaceutics, Glasgow 2016

  5. Yildir, E., Preis, M., Trygg, J., Fardim, P., Sandler, N. Physically and chemically modified CBs for the solubility enhancement of poorly soluble drugs. BBBB Conference, Helsinki 2015

  6. Preis, M., Sandler, N., Overcoming challenges in the manufacturing of orodispersible and buccal films. BBBB Conference Helsinki 2015

  7. Guhmann, M., Preis, M., Gerber, F., Pöllinger, N., Breitkreutz, J., Weitschies, W., Taste-masked micropellets of ibuprofen using an innovative spouted bed continuous pelletizing technology, 9th PBP World Meeting, Lisbon 2014

  8. Preis, M., Breitkreutz, J., How to determine suitable mechanical strength of orodispersible films? 5th Conference of the European Paediatric Formulation Initiative, Barcelona 2013

  9. Preis, M., Schneider, K., Kukawka, J., Broscheit, J., Roewer, N., Breitkreutz J., Development of bilayer oral films. 6th PSSRC Meeting, Lisbon 2012

  10. Eckert, C., Preis, M., Häusler, O., Breitkreutz, J., Comparative study on the taste masking capacity of hydroxypropyl-ß-cyclodextrin and maltodextrin by an electronic tongue. 8th PBP World Meeting, Istanbul 2012

  11. Pein M., Eckert, C., Preis, M., Breitkreutz, J., Taste sensing system αAstree as analytical tool – Performance Qualification using caffeine citrate as model substance. 8th PBP World Meeting, Istanbul 2012

  12. Preis, M., Breitkreutz, J., Enhancement of drug solubility in oral patch formulations by cyclodextrins and maltodextrin. 5th PSSRC Meeting, Helsinki 2011

 

Poster presentations

 

  1. H. Öblom, J. Berg, I. Alanko, M. Preis, N. Sandler, Thin substrates manufactured by means of 3D-printing for tailor-made drug delivery systems (EuPFI Special Issue, Abstract ID:7) International Journal of Pharmaceutics, 2016

  2. Yildir, E., Sjöholm, E., Preis, M., Trygg, J., Fardim, P., Sandler, N. Exploring cellulose discs as carriers in oromucosal drug delivery. World Meeting on Pharmaceutics and Biopharmaceutics, Glasgow 2016

  3. Palo, M., Kogermann, K., Laidmäe, I., Preis, M., Nyman, J.O., Heinämäki, J., Sandler, N. Electrospun fibrous gelatin substrates for inkjet printing. World Meeting on Pharmaceutics and Biopharmaceutics, Glasgow 2016

  4. Nyman, J.O., Preis, M., Wickström, H., Öblom, H., Desai, D., Nolvi, A., Kassmakov, I., Rosenholm, J., Hæggström, E., Sandler, N. Scanning White Light Interferometry – a powerful tool in pharmaceutical surface characterisation. World Meeting on Pharmaceutics and Biopharmaceutics, Glasgow 2016

  5. Palo, M., Kogermann, K., Laidmäe, I., Preis, M., Nyman, J.O., Heinämäki, J., Sandler, N. Electrospun nanofibrous substrates for inkjet-printed drug formulations. The 27th Annual Symposium if the Finnish Society of Physical Pharmacy, Helsinki 2016

  6. Vakili, H., Preis, M., Genina, N., Nyman, J.O., Sandler, N. Application of a colorimetric technique in quality control of tunable orodispersible formulations of propranolol hydrochloride. The 27th Annual Symposium if the Finnish Society of Physical Pharmacy, Helsinki 2016

  7. Yildir, E., Sjöholm, E., Preis, M., Trygg, J., Fardim, P., Sandler, N. Exploring cellulose discs as carriers in oromucosal drug delivery. The 27th Annual Symposium if the Finnish Society of Physical Pharmacy, Helsinki 2016

  8. Öblom, H., Preis, M., Berg, J., Alanko, I., Sandler, N. Tailor-made drug delivery systems manufactured by means of 3D printing. Farmasianpäivät, Helsinki 2015

  9. Öblom, H., Preis, M., Löbmann, K., Rades, T., Sandler, N. Solid-state characterization of co-amorphous formulations incorporated in thin film substrates manufactured by three-dimensional printing. AAPS Annual Meeting, Orlando 2015

  10. Nakano, K., Preis, M., Sandler, N. Application of three-dimensional printing to the fabrication of sustained release dosage form. AAPS Annual Meeting, Orlando 2015

  11. Yildir, E., Preis, M., Trygg, J., Fardim, P., Sandler, N. Physically and chemically modified Cellulose Beads for the solubility enhancement of poorly soluble drugs. AAPS Annual Meeting, Orlando 2015

  12. Thabet, Y., Krainitzki, L., Dietzel, D., Preis, M. Impact of different drying conditions on mechanical properties of orodispersible films. Annual Meeting of the German Pharmaceutical Society, Düsseldorf 2015

  13. Öblom, H., Berg, J., Alanko, I., Preis, M., Sandler, N. Thin substrates manufactured by means of 3D-printing - tailor-made drug delivery system for paediatric use. 7th Conference of the European Paediatric Formulation Initiative, Antwerp 2015

  14. Sieber, D., Krampe, R., Stolze, C., Lenhart, V., Preis, M., Breitkreutz, J. Fillet: A new dosage form combining orodispersible films and orodispersible tablets – Preparation concepts. European Meeting on Biopharmaceutics: Drug Delivery, Reims 2015

  15. Krampe, R., Sieber, D., R., Stolze, C., Lenhart, V., Preis, M., Breitkreutz, J. Fillet: A new dosage form combining orodispersible films and orodispersible tablets – Influence of different films and tablets. European Meeting on Biopharmaceutics: Drug Delivery, Reims 2015

  16. Preis, M., Breitkreutz, J., Development of novel disintegration test systems for orodispersible films. 9th PBP World Meeting, Lisbon 2014

  17. Preis, M., Broscheit, J., Roewer, N., Breitkreutz, J., Buccal films containing midazolam hydrochloride as an alternative to tablets in premedication, 9th PBP World Meeting, Lisbon 2014

  18. Preis, M., Schneider, K., Kukawka, J., Broscheit, J., Roewer, N., Breitkreutz, J., Development of bilayer oral films containing lidocaine hydrochloride. AAPS Annual Meeting and Exposition, Chicago 2012

  19. Guhmann, M., Preis, M., Gerber, F., Pöllinger, N., Breitkreutz, J., Weitschies, W., Development and evaluation of multiparticulate orally disintegrating tablets comprising diclofenac. Oral Multiparticulate Dosage Forms – What’s new? Prague 2012

  20. Preis, M., Broscheit, J., Roewer, N., Breitkreutz, J., Development of a palatable midazolam formulation for paediatric use. 4th Conference of the European Paediatric Formulation Initiative, Prague 2012

  21. Preis, M., Schneider, K., Kukawka, J., Broscheit, J., Roewer, N., Breitkreutz, J., Electronic taste assessment of bilayer orodispersible films. 4th Conference of the European Paediatric Formulation Initiative, Prague 2012

  22. Preis, M., Breitkreutz, J., Introduction of a new disintegration test for orodispersible films. 4th Conference of the European Paediatric Formulation Initiative, Prague 2012

  23. Preis, M., Woertz, C., Breitkreutz, J., Mucoadhesive polymer films – influence of thickness on disintegration time and mouthfeeling. 8th PBP World Meeting, Istanbul 2012

  24. Preis, M., Breitkreutz, J., Comparative etongue investigations on orodispersible dimenhydrinate formulations including combined data treatment. 8th PBP World Meeting, Istanbul 2012

  25. Guhmann, M., Preis, M., Gerber, F., Poellinger, N., Breitkreutz, J., Weitschies, W., Taste evaluation of different diclofenac salts in early pharmaceutical development stage using a taste sensing system. 8th PBP World Meeting, Istanbul 2012

  26. Hoffmann, E.M., Preis, M., Akyüz, G., Son, Ö., Breitenbach, A., Breitkreutz, J., Comparison of different disintegration tests for oral soluble films. AAPS Annual Meeting, Washington DC 2011

  27. Preis, M., Häusler, O., Breitkreutz, J., Electronic taste sensing system to evaluate taste-masking properties of maltodextrins. APGI Poorly Soluble Drugs Workshop, Lille 2011                                                 

  28. Preis, M., Breitkreutz, J., Development of an orodispersible mini-patch containing dimenhydrinate for the treatment of vomiting and nausea in the paediatric population. 3rd Conference of the European Paediatric Formulation Initiative, Straßburg 2011

  29. Preis, M., Wörtz, K., Breitkreutz, J., Taste assessment of orodispersible mini-patches containing dimenhydrinate by an electronic taste sensing system. 3rd Conference of the European Paediatric Formulation Initiative, Straßburg 2011

  30. Hoffmann, E.M., Preis, M., Akyüz, G., Son, Ö., Breitkreutz, J., Development of new disintegration tests for orodispersible films. 3rd Conference of the European Paediatric Formulation Initiative, Straßburg 2011

  31. Preis, M., Breitkreutz, J., Preparation and characterization of orodispersible films (ODFs) containing the local anesthetic lidocaine hydrochloride. 6th Polish German Symposium, Düsseldorf 2011

 

PhD Thesis:

 

Oromucosal film preparations for pharmaceutical use: formulation development and analytical characterization

University of Düsseldorf, Germany, June 2014.

(Available at: http://docserv.uni-duesseldorf.de/servlets/DerivateServlet/Derivate-32499/Preis_Maren_Dissertation_pdfA.pdf)

© 2016 Pharmaceutical Sciences Laboratory

Offical University Website:

https://www.abo.fi/amnen/farmaci/

Pharmaceutical Sciences

Åbo Akademi University

BioCity 3rd floor

Artillerigatan 6A

FI 20520 Turku

Finland

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